Mouse Monoclonal [clone MEM-258] (IgG1) to Human MCP / CD46

• Catalog number
  MBS245913
• Price
  Please ask
• Size
  0.05 mg

• Products_type
  Antibody
• Products_short_name
  [MCP / CD46]
• Products_name_syn
  [Anti-MCP / CD46 Antibody (clone MEM-258) IHC-plus; CD46; AHUS2; CD46 antigen; MCP; Measles virus receptor; TLX; MIC10; TRA2.10; Membrane cofactor protein; Human MCP; CD46]
• Other_names
  [membrane cofactor protein isoform 1; Membrane cofactor protein; membrane cofactor protein; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal antibody TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); CD46 molecule, complement regulatory protein; TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46]
• Products_gene_name
  [MCP]
• Products_gene_name_syn
  [CD46]
• Other_gene_names
  [CD46; CD46; MCP; TLX; AHUS2; MIC10; TRA2.10; MCP; MIC10]
• Clonality
  Monoclonal
• Clone
  [MEM-258]
• Reactivity
  Human
• Specificity
  Recognizes the human CD46 cell surface antigen, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP). CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases. CD46 is expressed by all nucleated cells, often as multiple isoforms on the same cells. The molecule is also expressed by sperm and may be important in the process of fertilization
• Purity
  Protein A Purified
• Form
  PBS, 0.09% sodium azide. Sourced in TCS.
• Concentration
  1 mg/ml
• Storage_stability
  Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
• Tested_application
  Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  Monoclonal   MEM-258]   IgG1   MCP   CD46  
• Gene symbol
  CD46, CAPG, CCL8, SLC25A33, CCL7, CCL13, CCR2, CCL2
• Short name
  Mouse Monoclonal [clone MEM-258] (IgG1) MCP / CD46
• Technique
  Mouse monoclonal, Mouse, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG1, IgG1
• Species
  Human, Humans, Mouses
• Alternative name
  Mouse monoclonal [clonality MEM-258] (IgG1) to H. sapiens MCP / CD46 molecule, complement regulatory protein
• Alternative technique
  murine
• Alternative to gene target
  CD46 molecule, complement regulatory protein, AHUS2 and MCP and MIC10 and TLX and TRA2.10, CD46 and IDBG-106372 and ENSG00000117335 and 4179, cadherin binding, Cell surfaces, Cd46 and IDBG-209330 and ENSMUSG00000016493 and 17221, BT.68611 and IDBG-638462 and ENSBTAG00000005397 and 280851
• Clone name
  MEM-258

Gene info

• Identity
  HGNC:6953
• Gene
  CD46
• Long gene name
  CD46 molecule
• Synonyms gene
  • MIC10
  • MCP
• Synonyms gene name
  • antigen identified by monoclonal antibody TRA-2-10
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • CD46 antigen, complement regulatory protein
  • CD46 molecule, complement regulatory protein
• Synonyms
  • TRA2.10
  • MGC26544
  • TLX
• GenBank acession
  • BC030594
• Locus
  1q32.2
• Discovery year
  1988-08-31
• Entrez gene record
  4179
• Pubmed identfication
  • 7929741
• RefSeq identity
  • NM_172361
• Classification
  • Sushi domain containing
  • Complement system regulators and receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000036397
• Locus Specific Databases
  • LRG_155

Gene info

• Identity
  HGNC:1474
• Gene
  CAPG
• Long gene name
  capping actin protein, gelsolin like
• Synonyms gene
  • AFCP
• Synonyms gene name
  • capping protein (actin filament), gelsolin-like
• Synonyms
  • MCP
• Synonyms name
  • macrophage capping protein
• GenBank acession
  • M94345
• Locus
  2p11.2
• Discovery year
  1993-12-14
• Entrez gene record
  822
• Pubmed identfication
  • 1322908
  • 12754261
• RefSeq identity
  • NM_001747
• Classification
  • Gelsolin/villins
• VEGA ID
  OTTHUMG00000130183

Gene info

• Identity
  HGNC:10635
• Gene
  CCL8
• Long gene name
  C-C motif chemokine ligand 8
• Synonyms gene
  • SCYA8
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
  • chemokine (C-C motif) ligand 8
• Synonyms
  • MCP-2
  • HC14
• GenBank acession
  • X99886
• Locus
  17q12
• Discovery year
  1996-11-14
• Entrez gene record
  6355
• Pubmed identfication
  • 9119400
• RefSeq identity
  • NM_005623
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132883

Gene info

• Identity
  HGNC:29681
• Gene
  SLC25A33
• Long gene name
  solute carrier family 25 member 33
• Synonyms gene name
  • solute carrier family 25, member 33
  • solute carrier family 25 (pyrimidine nucleotide carrier), member 33
• Synonyms
  • MGC4399
  • BMSC-MCP
  • PNC1
• GenBank acession
  • AF495714
• Locus
  1p36.22
• Discovery year
  2006-09-21
• Entrez gene record
  84275
• Pubmed identfication
  • 14715278
  • 16949250
• RefSeq identity
  • NM_032315
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000001322

Gene info

• Identity
  HGNC:10634
• Gene
  CCL7
• Long gene name
  C-C motif chemokine ligand 7
• Synonyms gene
  • SCYA6
  • SCYA7
• Synonyms gene name
  • small inducible cytokine A7 (monocyte chemotactic protein 3)
  • chemokine (C-C motif) ligand 7
• Synonyms
  • MCP-3
  • NC28
  • FIC
  • MARC
  • MCP3
• Synonyms name
  • monocyte chemoattractant protein 3
  • monocyte chemotactic protein 3
• GenBank acession
  • AF043338
• Locus
  17q12
• Discovery year
  1993-11-04
• Entrez gene record
  6354
• Pubmed identfication
  • 8461011
• RefSeq identity
  • NM_006273
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132889

Gene info

• Identity
  HGNC:10611
• Gene
  CCL13
• Long gene name
  C-C motif chemokine ligand 13
• Synonyms gene
  • SCYA13
• Synonyms gene name
  • small inducible cytokine subfamily A (Cys-Cys), member 13
  • chemokine (C-C motif) ligand 13
• Synonyms
  • MCP-4
  • NCC-1
  • SCYL1
  • CKb10
  • MGC17134
• GenBank acession
  • AJ001634
• Locus
  17q12
• Discovery year
  1997-02-11
• Entrez gene record
  6357
• Pubmed identfication
  • 8661057
• RefSeq identity
  • NM_005408
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132890

Gene info

• Identity
  HGNC:1603
• Gene
  CCR2
• Long gene name
  C-C motif chemokine receptor 2
• Synonyms gene
  • CMKBR2
• Synonyms gene name
  • chemokine (C-C motif) receptor 2
• Synonyms
  • CC-CKR-2
  • CKR2
  • MCP-1-R
  • CD192
  • FLJ78302
• Locus
  3p21.31
• Discovery year
  1995-05-30
• Entrez gene record
  729230
• Pubmed identfication
  • 8146186
• RefSeq identity
  • NM_000647
• Classification
  • C-C motif chemokine receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000156466

Gene info

• Identity
  HGNC:10618
• Gene
  CCL2
• Long gene name
  C-C motif chemokine ligand 2
• Synonyms gene
  • SCYA2
• Synonyms gene name
  • small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
  • chemokine (C-C motif) ligand 2
• Synonyms
  • MCP1
  • MCP-1
  • MCAF
  • SMC-CF
  • GDCF-2
  • HC11
  • MGC9434
• Synonyms name
  • monocyte chemotactic protein 1, homologous to mouse Sig-je
  • monocyte chemoattractant protein-1
  • monocyte chemotactic and activating factor
  • monocyte secretory protein JE
  • small inducible cytokine subfamily A (Cys-Cys), member 2
• GenBank acession
  • BC009716
• Locus
  17q12
• Discovery year
  1990-07-05
• Entrez gene record
  6347
• Pubmed identfication
  • 2004761
• RefSeq identity
  • NM_002982
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000132887

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