Dactinomycin

MeSH code information

• Name
  Dactinomycin
• Concept
  Registry number: 1CC1JFE158

  Scope note: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

  CASN1 number: Actinomycin D
• Tree numbers
  • D03.633.300.200
  • D04.345.566.252
  • D12.644.641.252
• Qualifiers
  isolation & purification, immunology, pharmacokinetics, biosynthesis, therapeutic use, agonists, blood, cerebrospinal fluid, chemical synthesis, chemistry, urine, radiation effects, history, analysis, classification, economics, pharmacology, standards, administration & dosage, antagonists & inhibitors, analogs & derivatives, supply & distribution, poisoning, adverse effects, toxicity, metabolism