Aromatase

MeSH code information

• Name
  Aromatase
• Concept
  Registry number: EC 1.14.14.1

  Scope note: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
• Tree numbers
  • D08.244.453.489.500
  • D08.244.453.915.099
  • D08.811.682.690.708.170.447.500
  • D08.811.682.690.708.170.915.099
  • D12.776.422.220.453.489.500
  • D12.776.422.220.453.915.099
• Qualifiers
  isolation & purification, immunology, pharmacokinetics, biosynthesis, physiology, therapeutic use, blood, cerebrospinal fluid, chemical synthesis, deficiency, chemistry, drug effects, urine, radiation effects, history, analysis, classification, economics, genetics, pharmacology, standards, administration & dosage, supply & distribution, ultrastructure, poisoning, adverse effects, toxicity, metabolism