Insulin

MeSH code information

• Name
  Insulin
• Concept
  Scope note: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
• Tree numbers
  • D06.472.699.587.200.500.625
  • D12.644.548.586.200.500.625
• Qualifiers
  isolation & purification, immunology, pharmacokinetics, biosynthesis, physiology, therapeutic use, agonists, blood, cerebrospinal fluid, chemical synthesis, deficiency, chemistry, urine, radiation effects, history, analysis, classification, economics, genetics, pharmacology, standards, administration & dosage, analogs & derivatives, supply & distribution, poisoning, adverse effects, toxicity, metabolism