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Also known as
Nerve Growth Factor Receptor, p75NTR
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Other names
nerve growth factor receptor; N/A; nerve growth factor receptor; NRH; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
ngfr; N/A; nrh1; CD271; NRH1b; p75ntr; p75(NTR); tnfrsf16; MGC131034; Gp80-LNGFR; N/A
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Gene name synonims
ngfr; N/A; nrh1; CD271; NRH1b; p75ntr; p75(NTR); tnfrsf16; MGC131034; Gp80-LNGFR; N/A
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Other gene names
ngfr; N/A; nrh1; CD271; NRH1b; p75ntr; p75(NTR); tnfrsf16; MGC131034; Gp80-LNGFR; N/A
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Clonality
Monoclonal
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Immunoglobulin isotype
IgG2A
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Clone
9G398
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Host organism
Mouse (Mus musculus)
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Source organism
Rat (Rattus norvegicus)
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Species reactivity
Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
Recognizes the extracellular domain of the neurotrophin receptor p75NTR in rat. MC192 antibody may be used for immunocytochemical localisation of rat cells expressing p75NTR, ELISA and western blot. Does not react with mouse.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
Affinity Purified by affinity chromatography.
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Form Appearance
Supplied as a liquid in PBS, pH 7.2. No preservative added.
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Concentration
N/A
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Storage and shipping
Store the antibody at +4 degrees Celsius. For long-term storage, aliquot and keep at +4 degrees Celsius for up to one year. Do not freeze. Aliquots are stable for up to 4 months. Prior to use, briefly centrifuge the original vial after thawing and before lid. If further dilution(s) are needed, they can be done with the appropriate assay buffer. Note: We do not recommended adding glycerol as a cryopreservative.
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Tested applications
ELISA (EL/EIA), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
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Test
A high affinity purification column was use to purify Nerve Growth Factor Receptor, p75NTR ( - NGF receptor, Gp80-LNGFR, p75 ICD, neurotrophin receptor p75NTR) by MBS Monoclonals by chromatographic size exclusion.
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
