Vandetanib, VEGFR inhibitor

• Catalog number
  SIH-483-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  443913-73-3
• Description
  VEGFR inhibitor
• Molecular weight
  475,4 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Growth Factor Receptor Inhibitors
• Other name
  N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C22H24BrFN4O2
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (HPLC)
• Soluble in
  Soluble in DMSO (30 mg/ml) or EtOH (10 mg/ml)
• Physical appearance
  Yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  3081361
• Scientific context
  Vandetanib is a specific inhibitor of Flk-1 and Flt-4.
• Bibliography
  1. Bruns C.J., et al. (2000) Clin. Cancer. Res: J. Am. Assoc. Cancer Res. 6(5): 1936–1948.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Vandetinib (SIH-483), a VEGFRK inhibitor. CAS #: 443913-73-3. Molecular Formula: C22H24BrFN4O2. Molecular Weight: 475.4 g/mol. Chemical structure of Vandetinib, a VEGFRK inhibitor (SIH-483). CAS # 443913-73-3. Molecular Formula: C22H24BrFN4O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Vandetanib   VEGFR   inhibitor  
• Gene symbol
  FLT4, KDR
• Short name
  Vandetanib, VEGFR inhibitor
• Alternative name
  Vandetanib, VEGFR suppressor

Gene info

• Identity
  HGNC:3767
• Gene
  FLT4
• Long gene name
  fms related receptor tyrosine kinase 4
• Synonyms gene name
  • fms-related tyrosine kinase 4
  • fms related tyrosine kinase 4
• Synonyms
  • VEGFR3
  • PCL
  • VEGFR-3
• Synonyms name
  • vascular endothelial growth factor receptor 3
  • VEGF receptor-3
  • Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
  • primary congenital lymphedema
• GenBank acession
  • X68203
• Locus
  5q35.3
• Discovery year
  1991-10-25
• Entrez gene record
  2324
• Pubmed identfication
  • 1319394
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
• VEGA ID
  OTTHUMG00000130931

Gene info

• Identity
  HGNC:6307
• Gene
  KDR
• Long gene name
  kinase insert domain receptor
• Synonyms gene name
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
• Synonyms
  • FLK1
  • VEGFR
  • VEGFR2
  • CD309
• Synonyms name
  • vascular endothelial growth factor receptor 2
  • fetal liver kinase 1
• GenBank acession
  • AF035121
• Locus
  4q12
• Discovery year
  1991-07-10
• Entrez gene record
  3791
• Pubmed identfication
  • 1417831
• Classification
  • Receptor tyrosine kinases
  • CD molecules
  • I-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000128734
• Locus Specific Databases
  • The Globin Gene Server
  • LRG_1198

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