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Stock availabilitIn Stock
In Stock
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CAS number
62996-74-1
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Description
Protein kinase inhibitor
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Molecular weight
466,54 g/mol
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Primary research fields
Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
(2S,3R,4R,6R)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C28H26N4O3
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Origin
Synthetic
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Purity pourcentage
>98% (TLC); NMR (Conforms)
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Soluble in
Soluble to 50 mM in DMSO
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Physical appearance
Pale Yellow Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H340- H350 Precautionary Phrases: P201-P308 + P313
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PubChem number
44259
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Scientific context
Staurosporine is a broad spectrum protein kinase inhibitor with activities ranging from anti-fungal to anti-hypertensive (1). Staurosporine is a typical ATP-competitive kinase inhibitor that binds to many kinases with high affinity, but with little selectivity (2).
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Bibliography
1. Ruegg U.T., and Burgess G.M. (1989) Trends in Pharm Science. 10(6): 218-220. 2. Karaman M.W., et al. (2008) Nat. Biotechnol. 26(1): 127-132.
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Release date
8-Apr-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Staurosporine (SIH-253), a Protein kinase inhibitor. CAS #: 62996-74-1. Molecular Formula: C28H26N4O3. Molecular Weight: 466.54 g/mol. Chemical structure of Staurosporine, a Protein kinase inhibitor (SIH-253). CAS # 62996-74-1. Molecular Formula: C28H26N4O3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
