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Stock availabilitIn Stock
In Stock
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CAS number
123-78-4
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Description
Protein Kinase C inhibitor
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Molecular weight
299,49 g/mol
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Primary research fields
Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C18H37NO2
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 100 mM in DMSO
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Physical appearance
Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
5280335
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Scientific context
Sphingosine can be phosphorylated in vivo via two kinases which leads to the formation of a potent signaling lipid. It is a selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. It also inhibits calmodulin-dependent enzymes and is the precursor of ceramide.
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Bibliography
1. Radin N. (2003) Biochem J. 371(Pt2): 243-256. 2. Carter H.E., Glick F.J., Norris W.P., Phillips G.E. (1947) J Biol Chem. 170: 285-295.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Sphingosine (SIH-202), a Protein Kinase C inhibitor. CAS #: 123-78-4. Molecular Formula: C18H37NO2. Molecular Weight: 299.49 g/mol. Chemical structure of Sphingosine, a Protein Kinase C inhibitor (SIH-202). CAS # 123-78-4. Molecular Formula: C18H37NO2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.025
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.