Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (SIGN-R1)

  • Catalog number
    GEN604030
  • Price
    Please ask
  • Size
    0.25 miligrams
  • Also known as
    Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1
  • Other names
    N/A
  • Category
    Antibodies
  • Subcategory
    Mnoclonal antibodies
  • Gene name
    N/A
  • Gene name synonims
    N/A
  • Other gene names
    N/A
  • Clonality
    Monoclonal
  • Immunoglobulin isotype
    IgM
  • Clone
    8J189
  • Host organism
    Rat (Rattus norvegicus)
  • Source organism
    Mouse (Mus musculus)
  • Species reactivity
    Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
  • Specificity and cross reactivity
    Recognizes mouse SIGN-R1, a C-type lectin that has been identified as a murine homolog of the human CD-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations. Blocks the uptake of neutral polysaccharides by macrophages.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
  • Purification method
    Purified by ammonium sulfate precipitation.
  • Form Appearance
    Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide
  • Concentration
    N/A
  • Storage and shipping
    Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
  • Tested applications
    Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
  • Description
    cell adhesion molecules play a role in cell growth and activation and are often identified by WB or ELISA as in the Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (SIGN-R1). Whole adhesion and interacting molecules are  present in lysates used as reference for ELISA quantification of these molecules and their subunits.
  • Gene target
  • Gene symbol
    CD209, C17orf75, CDCA7L, CNEP1R1, CXCL11, PNPLA7, PCAT6
  • Short name
    Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (SIGN-R1)
  • Technique
    intracellular
  • Alternative name
    Anti-Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (SIGN-R1)
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