Radicicol, Hsp90 inhibitor

• Catalog number
  SIH-117A
• Price
  Please ask
• Size
  1 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  12772-57-5
• Description
  Hsp90 inhibitor
• Molecular weight
  364,8 g/mol
• Primary research fields
  Cancer, Heat Shock
• Other name
  none
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C18H17CIO6
• Origin
  Produced by fermentation
• Purity pourcentage
  97% by TLC
• Soluble in
  Soluble in DMSO
• Physical appearance
  White to Yellow Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• PubChem number
  6323491
• Scientific context
  Radicicol inhibits src (IC50=0.27µM) and src-like kinases(1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein(2). It causes morphological reversion of ras-transformed cells(3) and leads to selective depletion of Raf kinase(4). It also displays anti-angiogenic activity(5), and binds to and inhibits Hsp 90 molecular chaperone(6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1. Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at more.
• Bibliography
  1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929. 2. Yen A., et al. (1994) Exp.Cell Res. 214: 163. 3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221. 4. Soga S., et al. (1998) J.Biol.Chem. 273: 822. 5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221. 6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Radicicol (SIH-117), a Hsp90 inhibitor. CAS #: 12772-57-5. Molecular Formula: C18H17CIO6. Molecular Weight: 364.8 g/mol. Chemical structure of Radicicol, a Hsp90 inhibitor (SIH-117). CAS # 12772-57-5. Molecular Formula: C18H17CIO6.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.001
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Radicicol   Hsp90   inhibitor  
• Short name
  Radicicol, Hsp90 inhibitor
• Alternative name
  Radicicol, Hsp90 suppressor

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