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Also known as
PAX6
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Other names
paired box protein Pax-6 isoform a; Paired box protein Pax-6; paired box protein Pax-6; oculorhombin; aniridia type II protein; paired box homeotic gene-6; paired box 6; Aniridia type II protein; Oculorhombin
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
PAX6
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Gene name synonims
N/A
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Other gene names
PAX6; PAX6; AN; AN2; FVH1; MGDA; WAGR; D11S812E; AN2
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Clonality
Monoclonal
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Immunoglobulin isotype
IgG1, kappa
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Clone
PAX6/496
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Host organism
Mouse (Mus musculus)
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Species reactivity
Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus), Chicken,; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters' anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
N/A
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Form Appearance
N/A
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Concentration
N/A
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Storage and shipping
Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
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Tested applications
ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
