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Stock availabilitIn Stock
In Stock
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CAS number
100286-90-6
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Description
Topoisomerase I inhibitor
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Molecular weight
623,14 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1,4'-bipiperidine-1'-carboxylate, CPT11, Camptothecin 11
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Product category
Small Molecules
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Product type
Inducer
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Chemical formula
C33H38N4O6•HCl
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 50 mg/ml in DMSO
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Physical appearance
Yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302
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PubChem number
74990
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Scientific context
Irinotecan is a topoisomerase 1 inhibitor, which prevents DNA from unwinding. Chemically it is a semisynthetic analogue of the natural alkaloid camptothecin. It is activated by hydrolysis to SN-38 which is then inactivated by glucuronidation by UGT1A1. This inactivation eventually leads to inhibition of both DNA replication and transcription (1, 2).
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Bibliography
1. Innocentri F., et al. (2004) J Clin. Oncol. 22(8): 1382-1388. 2. O’Dwyer P.J., and Catalano R.B. (2006) J Clin Oncol. 24(28): 4534-4538.
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Release date
8-Apr-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Irinotecan HCl (SIH-243), a Topoisomerase I inhibitor. CAS #: 100286-90-6. Molecular Formula: C33H38N4O6.HCl. Molecular Weight: 623.14 g/mol. Chemical structure of Irinotecan HCl, a Topoisomerase I inhibitor (SIH-243). CAS # 100286-90-6. Molecular Formula: C33H38N4O6.HCl.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.25
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
