F8, Coagulation factor VIII

• Catalog number
  IMS01-015-308
• Price
  Please ask
• Size
  100 µl (20 mg/ml)

• Available ordering format
  Liquid in 0.9% NaCl, 0.1% sodium azide
• Immunogen
  purified full length native human Coagulation Factor VIII-VWF-F VIII:c complex
• Raised in
  Hen
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Total IgY fraction
• How to reconstitute
  See included datasheet or contact our support service
• Storage condition
  store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
• Verified applications
  immunohistochemistry (IHC), ELISA (ELISA)
• Connected products
  IMS01-118-307 | anti-Coagulation factor VIIAS00 001 | anti-Coagulation factor VIIa AS05 058 | anti-Coagulation factor IXIMS01-137-306 | anti-Coagulation factor XIISecondary antibodies
• Recommended dilutions for use
  1: 200 (IHC)
• Molecular weight expected аpparent
  267 kDa
• Verified reactivity
  human
• Possible reactivity
  human
• No reactivity
  no confirmed exceptions from predicted reactivity known in the moment
• Supplementary information
  Immunohistochemistry: antibody was tested on bonin-fixed rat blood vessel.
• References
  to be added when available
• Scientific context
  The factor VIII complex, with a molecular weight in excess of 1 million, has 2 components: (1) factor VIII P00451 (molecular weight of 267 kDa) called factor VIII C, when measured by procoagulant activity or factor VIII Ag, when measured immunologically; (2) factor VIII R P04275 (the von Willebrand factor or vWF) has a molecular weight of 225 kDa. Factor VIII, along with calcium and phospholipids, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Domain F5/8 type C 2 Is responsible for phospholipid binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A (HEMA). HEMA is a common recessive X-linked coagulation disorder.
• Notes
  IgG concentration is 22.2 µg/µl
• Protein number
  Refer to NCBI
• TAIR number
  Refer to NCBI
• Hyperlink
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.

• Gene target
  Coagulation   factor   VIII  
• Gene symbol
  COX8A, G3BP1, MARCHF8
• Short name
  F8, Coagulation factor VIII
• Alternative name
  coagulation factor VIII, procoagulant component, Coagulation factor VIII
• Alternative to gene target
  coagulation factor VIII, procoagulant component, AHF and DXS1253E and F8B and F8C and FVIII and HEMA, F8 and IDBG-92134 and ENSG00000185010 and 2157, oxidoreductase activity, Extracellular, F8 and IDBG-157124 and ENSMUSG00000031196 and 14069, F8 and IDBG-632125 and ENSBTAG00000010726 and 100271720

Gene info

• Identity
  HGNC:2294
• Gene
  COX8A
• Long gene name
  cytochrome c oxidase subunit 8A
• Synonyms gene
  • COX8
• Synonyms gene name
  • cytochrome c oxidase subunit VIII
  • cytochrome c oxidase subunit VIIIA (ubiquitous)
• Synonyms
  • COX8-2
  • COX8L
  • VIII-L
  • COX
  • VIII
• GenBank acession
  • J04823
• Locus
  11q13.1
• Discovery year
  1989-06-30
• Entrez gene record
  1351
• Pubmed identfication
  • 2543673
  • 2847943
  • 26685157
• RefSeq identity
  • NM_004074
• Classification
  • Mitochondrial complex IV: cytochrome c oxidase subunits
• VEGA ID
  OTTHUMG00000167785

Gene info

• Identity
  HGNC:30292
• Gene
  G3BP1
• Long gene name
  G3BP stress granule assembly factor 1
• Synonyms gene name
  • GTPase activating protein (SH3 domain) binding protein 1
• Synonyms
  • HDH-VIII
  • G3BP
• Synonyms name
  • Ras-GTPase-activating protein SH3-domain-binding protein
  • DNA helicase VIII
• GenBank acession
  • BC006997
• Locus
  5q33.1
• Discovery year
  2006-10-25
• Entrez gene record
  10146
• Pubmed identfication
  • 8649363
  • 9889278
  • 25229650
• RefSeq identity
  • NM_005754
• Classification
  • RNA binding motif containing
  • Endoribonucleases
• VEGA ID
  OTTHUMG00000130123

Gene info

• Identity
  HGNC:23356
• Gene
  MARCHF8
• Long gene name
  membrane associated ring-CH-type finger 8
• Synonyms gene
  • MIR
  • MARCH8
• Synonyms gene name
  • c-mir, cellular modulator of immune recognition
  • membrane-associated ring finger (C3HC4) 8
  • membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
• Synonyms
  • c-MIR
  • CMIR
  • MARCH-VIII
  • RNF178
• GenBank acession
  • AL833316
• Locus
  10q11.21-q11.22
• Discovery year
  2003-11-12
• Entrez gene record
  220972
• Pubmed identfication
  • 12582153
  • 14722266
• RefSeq identity
  • NM_145021
• Classification
  • Ring finger proteins
  • Membrane associated ring-CH-type fingers
• VEGA ID
  OTTHUMG00000019345

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