F12, Coagulation factor XII
-
Catalog number
IMS01-137-306
-
Price
Please ask
-
Size
100 µl (15.1 mg/ml)
-
-
Available ordering format
Liquid in 0.9% NaCl, 0.1% sodium azide
-
Immunogen
purified full length native protein P00748
-
Raised in
Hen
-
Clonality
Polyclonal
-
Clone
Polyclonal
-
Purification
Total IgY fraction
-
How to reconstitute
See included datasheet or contact our support service
-
Storage condition
store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
-
Verified applications
ELISA (ELISA)
-
Connected products
IMS01-118-307 | anti-Coagulation factor VIIAS00 001 | anti-Coagulation factor VIIaIMS01-015-308 | anti-Coagulation factor VIIIAS05 058 | anti-Coagulation factor IXSecondary antibodies
-
Recommended dilutions for use
1: 10 000 (ELISA)
-
Molecular weight expected аpparent
67 kDa
-
Verified reactivity
human
-
Possible reactivity
human
-
No reactivity
no confirmed exceptions from predicted reactivity known in the moment
-
Supplementary information
detects human coagulation factor XII and XIIa
-
References
to be added when available
-
Scientific context
Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any apparent clinical symptoms and the sole effect is that whole blood clotting time is prolonged.
-
Notes
None
-
Protein number
P00748
-
TAIR number
Refer to NCBI
-
-
Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
-
Gene target
-
Gene symbol
F12, SIGLEC12
-
Short name
F12, Coagulation factor XII
-
Alternative name
F12, Coagulation factor XII
-
Gene info
-
Identity
-
Gene
-
Long gene name
coagulation factor XII
-
Synonyms gene name
- coagulation factor XII (Hageman factor)
-
GenBank acession
-
Locus
-
Discovery year
2001-06-22
-
Entrez gene record
-
RefSeq identity
-
VEGA ID
-
Locus Specific Databases
Gene info
Similar products
