D-LAP5, NMDA receptor antagonist

  • Catalog number
    SIH-413-50MG
  • Price
    Please ask
  • Size
    50 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    76326-31-3
  • Description
    NMDA receptor antagonist
  • Molecular weight
    197,13 g/mol
  • Primary research fields
    Neuroscience, Ion Channels, Neurotransmitter Receptors, Glutamate Receptors, NMDA Receptors
  • Other name
    DL-amino-5-phosphonopentaoic acid
  • Product category
    Small Molecules
  • Product type
    Antagonist
  • Chemical formula
    C5H12NO5P
  • Origin
    Synthetic
  • Purity pourcentage
    >99.0
  • Soluble in
    Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
  • Physical appearance
    White solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: D2B Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • PubChem number
    1216
  • Scientific context
    DLAP5 is a racemic mixture. It is used widely as a potent and selective NMDA receptor antagonist. It represents the active enantiomer form of AP5 (2-amino-5-phosphonopentanoic acid).
  • Bibliography
    1. Davies J., & Watkins J. (1982) Brain Res. 378-86. 2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7.
  • Release date
    21-May-2014
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of D-LAP5 (SIH-413), a Glutamate-NMDA receptor antagonist. CAS #: 76326-31-3. Molecular Formula: C5H12NO5P. Molecular Weight: 197.13 g/mol. Chemical structure of D-LAP5, a Glutamate-NMDA receptor antagonist (SIH-413). CAS # 76326-31-3. Molecular Formula: C5H12NO5P.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.05
  • Additional description
    The antagonist receptor ligand binding will be in contrast with agonist activity. stressma produces more antagonist and receptor related products as 1. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Gene target
  • Gene symbol
    SNAR-D, DGCR11, LY6G6D, OR1L3, ULK4P2, ULK4P1, IGHV3-38-3, VEGFD
  • Short name
    D-LAP5, NMDA receptor antagonist
  • Alternative name
    D-LAP5, NMDA receptor antagonist
Gene info
  • Identity
  • Gene
  • Long gene name
    small NF90 (ILF3) associated RNA D
  • Synonyms gene name
    • small ILF3/NF90-associated RNA D
  • GenBank acession
  • Locus
  • Discovery year
    2008-07-03
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Small NF90 (ILF3) associated RNAs
Gene info
  • Identity
  • Gene
  • Long gene name
    DiGeorge syndrome critical region gene 11
  • Synonyms gene name
    • DiGeorge syndrome critical region gene 11
    • DiGeorge syndrome critical region gene 11 (non-protein coding)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2002-11-13
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Long non-coding RNAs with non-systematic symbols
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    olfactory receptor family 1 subfamily L member 3
  • Synonyms gene name
    • olfactory receptor, family 1, subfamily L, member 3
  • Synonyms
  • Locus
  • Discovery year
    1999-12-09
  • Entrez gene record
  • Classification
    • Olfactory receptors, family 1
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    ULK4 pseudogene 2
  • Synonyms gene
  • Synonyms gene name
    • family with sequence similarity 7, member A2
    • unc-51-like kinase 4 (C. elegans) pseudogene 2
  • Synonyms
  • Locus
  • Discovery year
    2001-06-29
  • Entrez gene record
  • Pubmed identfication
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    ULK4 pseudogene 1
  • Synonyms gene
  • Synonyms gene name
    • family with sequence similarity 7, member A1
    • family with sequence similarity 7, member A1 (non-protein coding)
    • unc-51-like kinase 4 (C. elegans) pseudogene 1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-06-29
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • VEGA ID
Gene info
Gene info
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