D-LAP5, NMDA receptor antagonist
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Catalog numberSIH-413-50MG
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PricePlease ask
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Size50 mg
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Stock availabilitIn StockIn Stock
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CAS number76326-31-3
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DescriptionNMDA receptor antagonist
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Molecular weight197,13 g/mol
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Primary research fieldsNeuroscience, Ion Channels, Neurotransmitter Receptors, Glutamate Receptors, NMDA Receptors
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Other nameDL-amino-5-phosphonopentaoic acid
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Product categorySmall Molecules
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Product typeAntagonist
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Chemical formulaC5H12NO5P
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OriginSynthetic
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Purity pourcentage>99.0
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Soluble inSoluble to 10 mM in water and to 100 mM in 1eq. NaOH
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Physical appearanceWhite solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: D2B Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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PubChem number1216
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Scientific contextDLAP5 is a racemic mixture. It is used widely as a potent and selective NMDA receptor antagonist. It represents the active enantiomer form of AP5 (2-amino-5-phosphonopentanoic acid).
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Bibliography1. Davies J., & Watkins J. (1982) Brain Res. 378-86. 2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7.
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Release date21-May-2014
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of D-LAP5 (SIH-413), a Glutamate-NMDA receptor antagonist. CAS #: 76326-31-3. Molecular Formula: C5H12NO5P. Molecular Weight: 197.13 g/mol. Chemical structure of D-LAP5, a Glutamate-NMDA receptor antagonist (SIH-413). CAS # 76326-31-3. Molecular Formula: C5H12NO5P.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.05
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Additional descriptionThe antagonist receptor ligand binding will be in contrast with agonist activity. stressma produces more antagonist and receptor related products as 1. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbolSNAR-D, DGCR11, LY6G6D, OR1L3, ULK4P2, ULK4P1, IGHV3-38-3, VEGFD
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Short nameD-LAP5, NMDA receptor antagonist
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Alternative nameD-LAP5, NMDA receptor antagonist
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Gene info
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Identity
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Gene
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Long gene namesmall NF90 (ILF3) associated RNA D
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Synonyms gene name
- small ILF3/NF90-associated RNA D
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GenBank acession
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Locus
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Discovery year2008-07-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small NF90 (ILF3) associated RNAs
Gene info
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Identity
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Gene
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Long gene nameDiGeorge syndrome critical region gene 11
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Synonyms gene name
- DiGeorge syndrome critical region gene 11
- DiGeorge syndrome critical region gene 11 (non-protein coding)
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-13
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Entrez gene record
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Pubmed identfication
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Classification
- Long non-coding RNAs with non-systematic symbols
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelymphocyte antigen 6 family member G6D
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Synonyms gene
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Synonyms gene name
- chromosome 6 open reading frame 23
- lymphocyte antigen 6 complex, locus G6D
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Synonyms
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Locus
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Discovery year2002-04-05
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Entrez gene record
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Pubmed identfication
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Classification
- LY6/PLAUR domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 1 subfamily L member 3
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Synonyms gene name
- olfactory receptor, family 1, subfamily L, member 3
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Synonyms
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Locus
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Discovery year1999-12-09
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Entrez gene record
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Classification
- Olfactory receptors, family 1
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameULK4 pseudogene 2
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Synonyms gene
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Synonyms gene name
- family with sequence similarity 7, member A2
- unc-51-like kinase 4 (C. elegans) pseudogene 2
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Synonyms
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Locus
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Discovery year2001-06-29
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameULK4 pseudogene 1
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Synonyms gene
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Synonyms gene name
- family with sequence similarity 7, member A1
- family with sequence similarity 7, member A1 (non-protein coding)
- unc-51-like kinase 4 (C. elegans) pseudogene 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 3-38-3 (non-functional)
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Synonyms gene
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Synonyms gene name
- immunoglobulin heavy variable 3-D (provisional)
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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Pubmed identfication
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Classification
- Immunoglobulin heavy locus at 14q32.33
Gene info
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Identity
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Gene
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Long gene namevascular endothelial growth factor D
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Synonyms gene
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Synonyms gene name
- c-fos induced growth factor (vascular endothelial growth factor D)
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-03-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- VEGF family
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VEGA ID
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Locus Specific Databases