Cyclosporine, Immunosuppressant
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Catalog numberSIH-201-100MG
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PricePlease ask
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Size100 mg
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Stock availabilitIn StockIn Stock
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CAS number59865-13-3
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DescriptionImmunosuppressant
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Molecular weight1202,63 g/mol
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Primary research fieldsCancer, Apoptosis
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Other name(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC62H111N11O12
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OriginSynthetic
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Purity pourcentage>99%
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Soluble inSoluble to 100 mM in DMSO, 50 mM in ethanol
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Physical appearanceWhite Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed R45 - May cause cancer R62 - Possible risk of impaired fertility R68 - Possible risk of irreversible effects Hazard Phrases: H302-H350-H360 Precautionary Phrases: P201-P308 + P313
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PubChem number5284373
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Scientific contextCyclosporin A is a hydrophobic cyclic peptide, and is a potent immune-suppressant and antifungal. It acts via its ability to bind to a family of intracellular proteins (1). The immunosuppressant action is mediated by the complex Cyclosporin-A-cyclophilin that specifically inhibits the Ca2+/calmodulin-dependent serine-threonine-protein phosphatase-2B. This is turn inhibits calcineurin and promotes dephosphorylation of transcription factor NF-AT and T-cell activation (2).
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Bibliography1. Heitman J., et al. (1992) New Biol. 4:448. 2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.
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Release date8-Apr-2011
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of Cyclosporine (SIH-201), a Inhibits mitochondrial permeability pore opening. CAS #: 59865-13-3. Molecular Formula: C62H111N11O12 . Molecular Weight: 1202.63 g/mol. Chemical structure of Cyclosporine, a Inhibits mitochondrial permeability pore opening (SIH-201). CAS # 59865-13-3. Molecular Formula: C62H111N11O12 .
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.1
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Gene target
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Short nameCyclosporine, Immunosuppressant
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Alternative nameCyclosporine, Immunosuppressant
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