Cyclosporine A for cell activation
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B.
Antibiotic S 7481F1, Cyclosporine
Is this a salt?
Is it cell-permeable?
DMSO and EtOH
Maximum time for storage
Protect from light and air
For cells, cell lines and tissues in culture till half confluency.
Scope note:A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
CASN1 number:Cyclosporin A
immunology, pharmacokinetics, therapeutic use, toxicity, poisoning, administration & dosage, adverse effects, agonists, blood, cerebrospinal fluid, chemical synthesis, contraindications, chemistry, urine, radiation effects, history, analysis, antagonists & inhibitors, classification, economics, isolation & purification, metabolism, pharmacology, standards, supply & distribution