CFH, Complement factor H

• Catalog number
  IMS01-066-309
• Price
  Please ask
• Size
  100 µl (25.2 mg/ml)

• Available ordering format
  Liquid in 0.9% NaCl, 0.1% sodium azide
• Immunogen
  purified full length native protein P08603
• Raised in
  Hen
• Clonality
  Polyclonal
• Clone
  Polyclonal
• Purification
  Total IgY fraction
• How to reconstitute
  See included datasheet or contact our support service
• Storage condition
  store at 4°C; make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
• Verified applications
  immunodifusion (ID)
• Connected products
  IMS02-032-303 | anti-Complement component C4IMS06-032-304 | anti-Complement component C4, biotinylatedIMS01-031-305 | anti-Complement component C4cSecondary antibodies
• Recommended dilutions for use
  1: 32 (ID)
• Molecular weight expected аpparent
  140 kDa
• Verified reactivity
  human
• Possible reactivity
  human
• No reactivity
  no confirmed exceptions from predicted reactivity known in the moment
• Supplementary information
  Only one precipitin arc in immunodiffusion against normal human serum, dilution 1:10, or human factor H (β1H). Only one precipitin arc in immunoelectrophoresis against normal human serum or human factor H (β1H).
• References
  to be added when available
• Scientific context
  The Complement factor H protein is secreted into the bloodstream and acts in the regulation of complement activation. Mutations leading to changes in this protein have been linked with HUS (hemolytic-uremic syndrome) and chronic hypocomplementemic nephropathy.
• Notes
  the IgY fraction is isolated by a two-step PEG precipitation procedure followed by ammonium sulphate precipitation
• Protein number
  P08603
• TAIR number
  Refer to NCBI
• Hyperlink
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.

• Gene target
  CFH   Complement   factor  
• Gene symbol
  CFH
• Short name
  CFH, Complement factor H
• Alternative name
  complement factor H, Complement factor H
• Alternative to gene target
  complement factor H, AHUS1 and AMBP1 and ARMD4 and ARMS1 and CFHL3 and FH and FHL1 and HF and HF1 and HF2 and HUS, CFH and IDBG-105504 and ENSG00000000971 and 3075, heparan sulfate proteoglycan binding, Extracellular

Gene info

• Identity
  HGNC:4883
• Gene
  CFH
• Long gene name
  complement factor H
• Synonyms gene
  • HF
  • HF1
  • HF2
• Synonyms gene name
  • H factor 1 (complement)
• Synonyms
  • HUS
  • FHL1
  • ARMS1
  • ARMD4
• Synonyms name
  • beta-1H
  • H factor 2 (complement)
  • age-related maculopathy susceptibility 1
• GenBank acession
  • Y00716
• Locus
  1q31.3
• Discovery year
  1986-01-01
• Entrez gene record
  3075
• Pubmed identfication
  • 2889480
  • 2963625
• RefSeq identity
  • NM_000186
• Classification
  • Sushi domain containing
  • Complement system regulators and receptors
• VEGA ID
  OTTHUMG00000035607
• Locus Specific Databases
  • CFHbase: Mutation registry for Factor H deficiency (previously known as HF1base)
  • LRG_47

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