Brefeldin A, GEF inhibitor

• Catalog number
  SIH-225-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  20350-15-6
• Description
  GEF inhibitor
• Molecular weight
  280,36 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  Cyanaein
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C16H24O4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 10 mM in ethanol and to 50 mM in DMSO
• Physical appearance
  White Crystalline Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effects Hazard Phrases: H301 Precautionary Phrases: P301 + P310
• PubChem number
  5287620
• Scientific context
  Brefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).
• Bibliography
  1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Brefeldin A (SIH-225), a Inhibits intracellular transport. CAS #: 20350-15-6. Molecular Formula: C16H24O4. Molecular Weight: 280.36 g/mol. Chemical structure of Brefeldin A, a Inhibits intracellular transport (SIH-225). CAS # 20350-15-6. Molecular Formula: C16H24O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Brefeldin   GEF   inhibitor  
• Gene symbol
  RAPGEF5, RAPGEF6, ARHGEF2, RAPGEF2, SLC2A4RG
• Short name
  Brefeldin A, GEF inhibitor
• Alternative name
  Brefeldin A, GEF suppressor

Gene info

• Identity
  HGNC:16862
• Gene
  RAPGEF5
• Long gene name
  Rap guanine nucleotide exchange factor 5
• Synonyms gene name
  • Rap guanine nucleotide exchange factor (GEF) 5
• Synonyms
  • KIAA0277
  • GFR
  • MR-GEF
• Synonyms name
  • M-Ras-regulated GEF
• GenBank acession
  • D87467
• Locus
  7p15.3
• Discovery year
  2004-03-01
• Entrez gene record
  9771
• Pubmed identfication
  • 9039502
  • 10486569
• RefSeq identity
  • NM_012294
• VEGA ID
  OTTHUMG00000152525

Gene info

• Identity
  HGNC:20655
• Gene
  RAPGEF6
• Long gene name
  Rap guanine nucleotide exchange factor 6
• Synonyms gene
  • PDZGEF2
• Synonyms gene name
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 2
  • Rap guanine nucleotide exchange factor (GEF) 6
• Synonyms
  • RA-GEF-2
  • PDZ-GEF2
• GenBank acession
  • AF117947
• Locus
  5q31.1
• Discovery year
  2003-09-03
• Entrez gene record
  51735
• Pubmed identfication
  • 11524421
  • 12095257
• RefSeq identity
  • NM_016340
• Classification
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000162683

Gene info

• Identity
  HGNC:682
• Gene
  ARHGEF2
• Long gene name
  Rho/Rac guanine nucleotide exchange factor 2
• Synonyms gene name
  • rho/rac guanine nucleotide exchange factor (GEF) 2
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2
• Synonyms
  • LFP40
  • GEF-H1
  • KIAA0651
  • P40
  • Lfc
  • GEFH1
• GenBank acession
  • AB014551
• Locus
  1q22
• Discovery year
  2000-06-09
• Entrez gene record
  9181
• Pubmed identfication
  • 9857026
  • 9734811
• RefSeq identity
  • NM_004723
• Classification
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000017464

Gene info

• Identity
  HGNC:16854
• Gene
  RAPGEF2
• Long gene name
  Rap guanine nucleotide exchange factor 2
• Synonyms gene
  • PDZGEF1
• Synonyms gene name
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 1
  • Rap guanine nucleotide exchange factor (GEF) 2
• Synonyms
  • PDZ-GEF1
  • RA-GEF
  • DKFZP586O1422
  • KIAA0313
• Synonyms name
  • Rap GEP
• GenBank acession
  • AB002311
• Locus
  4q32.1
• Discovery year
  2003-05-20
• Entrez gene record
  9693
• Pubmed identfication
  • 9205841
  • 10934204
• RefSeq identity
  • NM_014247
• Classification
  • MicroRNA protein coding host genes
  • PDZ domain containing
• VEGA ID
  OTTHUMG00000161451

Gene info

• Identity
  HGNC:15930
• Gene
  SLC2A4RG
• Long gene name
  SLC2A4 regulator
• Synonyms
  • GEF
  • HDBP1
  • Si-1-2
  • Si-1-2-19
• Synonyms name
  • GLUT4 enhancer factor
  • Huntington's disease gene regulatory region-binding protein 1
• GenBank acession
  • AF249267
• Locus
  20q13.33
• Discovery year
  2001-06-21
• Entrez gene record
  56731
• Pubmed identfication
  • 10825161
• RefSeq identity
  • NM_020062
• VEGA ID
  OTTHUMG00000032997

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