Bml-278 SIRT1 activator, SIRT1 activator

  • Catalog number
    SIH-349-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    No Available. See included datasheet
  • Description
    SIRT1 activator
  • Molecular weight
    391,5 g/mol
  • Primary research fields
    Cell Signaling, Epigenetics
  • Other name
    N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C24H25NO4
  • Origin
    Synthetic
  • Purity pourcentage
    >98% (TLC), NMR conforms
  • Soluble in
    Soluble in 5 mg/ml DMSO
  • Physical appearance
    Off-White Solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
  • PubChem number
    Refer to PubChem
  • Scientific context
    A structurally novel activator of SIRT1 (EC150=1 µM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50 µM respectively). Cell permeable.
  • Bibliography
    1. Mai A., et al. (2009) J. Med. Chem. 52: 5496.
  • Release date
    1-Aug-2012
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of BML-278 SIRT1 activator (SIH-349), a SIRT1 activator. CAS #: N/A. Molecular Formula: C24H25NO4. Molecular Weight: 391.5 g/mol. Chemical structure of BML-278 SIRT1 activator, a SIRT1 activator (SIH-349). CAS # N/A. Molecular Formula: C24H25NO4.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Gene target
  • Gene symbol
    SIRT1-AS, SIRT1
  • Short name
    Bml-278 SIRT1 activator, SIRT1 activator
  • Alternative name
    Bml-278 sirtuin 1 activator, sirtuin 1 activator
  • Alternative to gene target
    sirtuin 1, SIR2L1, SIRT1 and IDBG-75847 and ENSG00000096717 and 23411, keratin filament binding, nuclei, Sirt1 and IDBG-159441 and ENSMUSG00000020063 and 93759, SIRT1 and IDBG-629119 and ENSBTAG00000014023 and 613629
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    sirtuin 1
  • Synonyms gene name
    • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1
    • sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-03-20
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • eNoSC complex
    • Sirtuins
  • VEGA ID
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