AS-2444697 Hydrochloride

• Catalog number
  B1585-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697
• Description
  AS-2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC₅₀ = 21 nM). It exhibits 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro.
• CAS Number
  1287665-60-4
• Structure Available
  Yes
• Molecular Formula
  C₉H₂₁ClN₆O₄
• Molecular Weight
  432.86
• Cell Permeable
  yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• SMILES
  Cl.Cc1nccc(c1)c2occ(n2)C(=O)Nc3cn(nc3C(N)=O)C4CCOCC4
• InChi
  InChI=1S/C19H20N6O4.ClH/c1-11-8-12(2-5-21-11)19-23-15(10-29-19)18(27)22-14-9-25(24-16(14)17(20)26)13-3-6-28-7-4-13;/h2,5,8-10,13H,3-4,6-7H2,1H3,(H2,20,26)(H,22,27);1H
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AS-2444697   Hydrochloride  
• Gene symbol
  KRT7-AS, DM1-AS, LRP1-AS, APOA1-AS, SIRT1-AS, ATXN2-AS, IRAIN, CTBP1-AS, HLA-B, EVX1-AS
• Short name
  AS-2444697 Hydrochloride
• Alternative name
  AS-2444697 Hydrochloride

Gene info

• Identity
  HGNC:52643
• Gene
  KRT7-AS
• Long gene name
  KRT7 antisense RNA 1
• Locus
  12q13.13
• Discovery year
  2016-11-18
• Entrez gene record
  109729127
• Pubmed identfication
  • 26876208
• RefSeq identity
  • NR_146274
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000169581

Gene info

• Identity
  HGNC:53125
• Gene
  DM1-AS
• Long gene name
  DM1 locus antisense RNA
• Locus
  19q13.32
• Discovery year
  2017-02-16
• Entrez gene record
  109729182
• Pubmed identfication
  • 28102759
• RefSeq identity
  • NR_147193
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:51694
• Gene
  LRP1-AS
• Long gene name
  LRP1 antisense RNA
• Locus
  12q13.3
• Discovery year
  2015-05-07
• Entrez gene record
  105751187
• Pubmed identfication
  • 25937287
• RefSeq identity
  • NR_131938
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000171280

Gene info

• Identity
  HGNC:40079
• Gene
  APOA1-AS
• Long gene name
  APOA1 antisense RNA
• GenBank acession
  • DA327409
• Locus
  11q23.3
• Discovery year
  2014-01-04
• Entrez gene record
  104326055
• Pubmed identfication
  • 24388749
• RefSeq identity
  • NR_126362
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000150649

Gene info

• Identity
  HGNC:51912
• Gene
  SIRT1-AS
• Long gene name
  SIRT1 antisense RNA
• Locus
  10q21.3
• Discovery year
  2015-09-23
• Entrez gene record
  106633813
• Pubmed identfication
  • 26324025
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:51838
• Gene
  ATXN2-AS
• Long gene name
  ATXN2 antisense RNA
• Locus
  12q24.12
• Discovery year
  2016-05-12
• Entrez gene record
  102723619
• Pubmed identfication
  • 27531668
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000169599

Gene info

• Identity
  HGNC:50365
• Gene
  IRAIN
• Long gene name
  IGF1R antisense imprinted non-protein coding RNA
• Synonyms
  • IGF1R-AS
• Synonyms name
  • IGF1R antisense RNA
• Locus
  15q26.3
• Discovery year
  2014-08-07
• Entrez gene record
  104472848
• Pubmed identfication
  • 25092925
  • 27644252
• RefSeq identity
  • NR_126453
• Classification
  • Long non-coding RNAs with non-systematic symbols
• Locus Specific Databases
  • LRG_1064

Gene info

• Identity
  HGNC:48337
• Gene
  CTBP1-AS
• Long gene name
  CTBP1 antisense RNA
• Synonyms
  • PCAT10
• Synonyms name
  • prostate cancer associated transcript 10
• GenBank acession
  • AX747592
  • AK092548
• Locus
  4p16.3
• Discovery year
  2013-06-14
• Entrez gene record
  285463
• Pubmed identfication
  • 23644382
  • 25552498
• RefSeq identity
  • NR_104331
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000189534

Gene info

• Identity
  HGNC:4932
• Gene
  HLA-B
• Long gene name
  major histocompatibility complex, class I, B
• Synonyms gene
  • AS
• Synonyms gene name
  • ankylosing spondylitis
• GenBank acession
  • M15470
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  3106
• Pubmed identfication
  • 3459708
• RefSeq identity
  • NM_005514
• Classification
  • C1-set domain containing
  • Histocompatibility complex
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000031153
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:40223
• Gene
  EVX1-AS
• Long gene name
  EVX1 antisense RNA
• Synonyms gene name
  • EVX1 antisense RNA (non-protein coding)
• Synonyms
  • EVX1-AS1
• Synonyms name
  • EVX1 antisense RNA 1 (non-protein coding)
• GenBank acession
  • DB455833
  • DB260732
• Locus
  7p15.2
• Discovery year
  2012-05-03
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000159991

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