anti- FAS/CD95 antibody
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Catalog numberFNab03016
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PricePlease ask
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Size2X100μg
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Formliquid
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PurificationImmunogen affinity purified
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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BackgroundThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
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ImmunogenFas (TNF receptor superfamily, member 6)
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SynonymsALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6
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Calculated MWRefer to figures
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Uniprot IDP25445
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SpecificityHuman, Mouse, Rat
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Tested ApplicationELISA, WB, IHC
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Recommended dilutionWB: 1:500 - 1:2000; IHC: 1:50 - 1:100
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Image1Immunohistochemistry of paraffin-embedded human prostate cancer using FNab03016(FAS antibody) at dilution of 1:100
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Image4HeLa cells were subjected to SDS PAGE followed by western blot with FNab03016(FAS antibody) at dilution of 1:1000
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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PropertiesIf you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolFAS, FAS-AS1, FASN
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Short nameanti- FAS/CD95 antibody
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TechniqueAntibody, anti, antibody to, antibodies against human proteins, antibodies for
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HostRabbit
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IsotypeIgG
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Alternative nameantibody to- Fas (tumor necrosis factor receptor superfamily, member 6)/CD95 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetFas (TNF receptor superfamily, member 6), ALPS1A and APO-1 and APT1 and CD95 and FAS1 and FASTM and TNFRSF6, FAS and IDBG-81669 and ENSG00000026103 and 355, identical protein binding, nuclei, Fas and IDBG-159577 and ENSMUSG00000024778 and 14102, FAS and IDBG-637356 and ENSBTAG00000010785 and 282488
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Gene info
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Identity
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Gene
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Long gene nameFas cell surface death receptor
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 6
- Fas (TNF receptor superfamily, member 6)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-06-25
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor receptor superfamily
- Death inducing signaling complex
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameFAS antisense RNA 1
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Synonyms gene
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Synonyms gene name
- FAS antisense RNA (non-protein coding)
- FAS antisense RNA 1 (non-protein coding)
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Synonyms
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Locus
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Discovery year2009-07-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene namefatty acid synthase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1994-05-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Short chain dehydrogenase/reductase superfamily
- 7BS orphan methyltransferases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data