Recombinant Human GDNF Family Receptor α-1/GFRA1 Protein(C-Fc)

• Catalog number
  PKSH032481-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  GDNF Family Receptor Alpha-1; GDNF Receptor Alpha-1; GDNFR-Alpha-1; GFR-Alpha-1; RET Ligand 1; TGF-Beta-Related Neurotrophic Factor Receptor 1; GFRA1; GDNFRA; RETL1; TRNR1
• Activity
  NA
• Sequence
  Asp25-Lys429
• Fusion tag
  C-Fc
• Accession
  P56159
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞90% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  72.3 kDa
• AP Mol Mass
  85 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Background
  Glial Cell Line-Derived Neurotrophic Factor Family Receptor α-1 (GDNFRα1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor α subtype which consists of at least four members. GFRα1and GFRα2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFRαs released enzymatically from the cell surface by phosphatidylinositol phospholipase C, as well as recombinantly produced soluble GFRα1, can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFRα1 shares 93% amino acid identity with mouse GFRα1.The expression of the various GFRαs are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFRαs in mediating the activities of the GDNF family of neurotrophic factors.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  GDNF   Family   Receptor   α-1/GFRA1   Protein   C-Fc  
• Gene symbol
  GDNF, GDNF-AS1, GFRA1
• Short name
  Recombinant GDNF Family Receptor α-1/GFRA1 Protein(C-Fc)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens glial cell derived neurotrophic factor family Receptor α-1/GFRA1 Protein(C-fragment c)
• Alternative technique
  rec
• Alternative to gene target
  glial cell derived neurotrophic factor, ATF1 and ATF2 and HFB1-GDNF and HSCR3, GDNF and IDBG-17169 and ENSG00000168621 and 2668, protein homodimerization activity, Extracellular, Gdnf and IDBG-128378 and ENSMUSG00000022144 and 14573, BT.58072 and IDBG-630047 and ENSBTAG00000005176 and 386587

Gene info

• Identity
  HGNC:4232
• Gene
  GDNF
• Long gene name
  glial cell derived neurotrophic factor
• Synonyms
  • ATF1
  • ATF2
  • HFB1-GDNF
• Synonyms name
  • astrocyte-derived trophic factor
  • glial cell line derived neurotrophic factor
  • glial derived neurotrophic factor
• Locus
  5p13.2
• Discovery year
  1995-05-04
• Entrez gene record
  2668
• Pubmed identfication
  • 8493557
• RefSeq identity
  • NM_000514
• Classification
  • GDNF family ligands
• VEGA ID
  OTTHUMG00000090809

Gene info

• Identity
  HGNC:43592
• Gene
  GDNF-AS1
• Long gene name
  GDNF antisense RNA 1
• Synonyms gene name
  • GDNF antisense RNA 1 (non-protein coding)
  • GDNF antisense RNA 1
  • GDNF antisense RNA 1 (head to head)
• Synonyms
  • GDNFOS
• Synonyms name
  • GDNF opposite strand
• GenBank acession
  • DA359107
• Locus
  5p13.2
• Discovery year
  2011-11-16
• Entrez gene record
  100861519
• Pubmed identfication
  • 22081608
• RefSeq identity
  • NR_103441
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000162110

Gene info

• Identity
  HGNC:4243
• Gene
  GFRA1
• Long gene name
  GDNF family receptor alpha 1
• Synonyms gene
  • GDNFRA
• Synonyms
  • RETL1
  • GDNFR
  • GFR-ALPHA-1
  • RET1L
  • TRNR1
• GenBank acession
  • AF038421
• Locus
  10q25.3
• Discovery year
  1997-01-17
• Entrez gene record
  2674
• Pubmed identfication
  • 9465905
  • 9545641
• RefSeq identity
  • NM_145793
• VEGA ID
  OTTHUMG00000019097

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products