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Activin-A Recombinant Protein

  • Catalog number
    40-544
  • Product name
    Activin-A Recombinant Protein
  • Size
    0.01 mg
  • Price
    357.50 EUR
  • Supplier
  • About recombinant protein
    Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Recombinant human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
  • Other name of the recombinant
    JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2
  • Recombinant in
    E. coli
  • His tag on the recombinant protein
    no His tag
  • SEQUENCE
    GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
  • Activity
    Biological activity was determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is &le; 2.0 ng/mL, corresponding to a specific activity of &ge; 5 x 10<sup>5</sup> units/mg. Endotoxin level is less than 0.1 ng per &#956;g (1EU/&#956;g).
  • Keep at
    The lyophilized Activin-A recombinant protein is stable for at least 2 years from date of receipt at -20&#730;C. Reconstituted Activin-A stable for at least 3 months when stored in working aliquots with a carrier protein at -20&#730;C. As with any protein, exposing Activin-A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • Rec. PROTEIN GI#
    51173730
  • Accession nr
    NP_001003652.1
  • Pureity
    Greater than 97% by SDS-PAGE gel and HPLC analyses.
  • About
    This product is for research use only.
  • Protein's origin
    Human
  • Vial
    Lyophilized
  • NCBI ID
    4087
  • Gene name
    SMAD family member 2
  • Source
    Homo sapiens
  • Uniprot
    Q15796
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Gene symbol
    SMAD2
  • Short name
    Activin-A Recombinant Protein
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Alternative name
    Activin-A recombinant Protein
  • Alternative technique
    rec
MESH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
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