Rabbit anti Lass6

• Catalog number
  X2303P
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.
• Antibody come from
  Synthetic peptide derived from the human SET protein
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti Lass6 Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western blot
• Antibody s suited for
  Antibody can be used for Western blotting (1:400 dilution). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -80ºC
• Relevant references
  [1] von Lindern M., van Baal S., Wiegant J., Raap A., Hagemeijer A., Grosveld G.;_x000B_ Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.; Mol. Cell. Biol. 12:3346-3355(1992)._x000B_[2] von Lindern M., van Baal S., Wiegant J., Raap A., Hagemeijer A., Grosveld G.;_x000B_Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.; Mol. Cell. Biol. 12:3346-3355(1992)._x000B_[3] Vaesen M., Barnikol-Watanabe S., Goetz H., Adil Awni L., Cole T., Zimmermann B., Kratzin H.D., Hilschmann N.; Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII.; Biol. Chem. Hoppe-Seyler 375:113-126(1994)._x000B_[4] Nagata K., Kawase H., Handa H., Yano K., Yamasaki M., Ishimi Y., Okuda A., Kikuchi A., Matsumoto K.; Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.; Proc. Natl. Acad. Sci. U.S.A. 92:4279-4283(1995)._x000B_[5] Li M., Makkinje A., Damuni Z.; The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A.; J. Biol. Chem. 271:11059-11062(1996)._x000B_[6] Tsujio I., Zaidi T., Xu J., Kotula L., Grundke-Iqbal I., Iqbal K.; Inhibitors of protein phosphatase-2A from human brain: structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated Tau.;_x000B_Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases._x000B_[7] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).; Genome Res. 14:2121-2127(2004)._x000B_[8] Adachi Y., Pavlaki G.N., Copeland T.D.; Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia.; J. Biol. Chem. 269:2258-2262(1994)._x000B_[9] Wang L.C., Chen Y.; A relative factor in human rectum carcinoma.; Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases._x000B_[10] Carlson S.G., Eng E., Kim E.-G., Perlman E.J., Copeland T.D., Ballermann B.J.;_x000B_Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor.; J. Am. Soc. Nephrol. 9:1873-1880(1998)._x000B_[11] Seo S.-B., McNamara P., Heo S., Turner A., Lane W.S., Chakravarti D.;_x000B_Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the Set oncoprotein.; Cell 104:119-130(2001)._x000B_[12] Minakuchi M., Kakazu N., Gorrin-Rivas M.J., Abe T., Copeland T.D., Ueda K., Adachi Y.; Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET.; Eur. J. Biochem. 268:1340-1351(2001)._x000B_[13] Fan Z., Beresford P.J., Zhang D., Lieberman J.; HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.; Mol. Cell. Biol. 22:2810-2820(2002)._x000B_[14] Fan Z., Beresford P.J., Oh D.Y., Zhang D., Lieberman J.; Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.; Cell 112:659-672(2003)._x000B_[15] Fan Z., Beresford P.J., Oh D.Y., Zhang D., Lieberman J.; Cell 115:241-241(2003)._x000B_[16] Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;_x000B_Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.;_x000B_Cell 127:635-648(2006)._x000B_[17] Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.; Mol. Cell 23:607-618(2006)._x000B_[18] Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  Lass6  
• Gene symbol
  CERS6
• Short name
  Rabbit anti Lass6
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to Lass6
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:23826
• Gene
  CERS6
• Long gene name
  ceramide synthase 6
• Synonyms gene
  • LASS6
• Synonyms gene name
  • LAG1 longevity assurance homolog 6 (S. cerevisiae)
  • LAG1 homolog, ceramide synthase 6
• GenBank acession
  • BX393696
• Locus
  2q24.3
• Discovery year
  2004-04-30
• Entrez gene record
  253782
• RefSeq identity
  • NM_203463
• Classification
  • CERS class homeoboxes
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000132183

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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