Rabbit anti HDAC1

  • Catalog number
    X1847P
  • Price
    Please ask
  • Size
    50 μg
  • Category
    Primary Antibodies
  • Long description
    Acetylation of the tail of histone is known to cause chromatin to adopt a more ÔopenÕ 3D conformation, allowing trans factors grerater access to DNA. Histone acetyltransferases (HATs), complexes interact with sequence-specific activator proteins and target specific genes. In addition to histones, HATs acetylate non-histone proteins, implicating them in a wide variety of regulartory roles for these enzymes. By comparison, histone deacetylation promotes a more ÔclosedÕ chromatin conformation and in general leads to repression of gene activity. Mammalian histone deacetylases are divided into three classes on the basis of their similarity to various the yeast deacetylases. Class I (HDACs 1, 2, 3 and 8) related to the yeast Rpd3-like proteins, class II (HDACs 4, 5, 6, 7, 9 and 10) related to yeast Hda1-like proteins and class III related to the yeast protein Sir2. Inhibitors of HDAC have enormous potential as cancer therapeutic agents.
  • Antibody come from
    Recombinant SMSr derived from Drosophila .
  • Other description
    Provided as solution in phosphate buffered saline with 0.08% sodium azide. Antigen Immunoaffiinity Purification
  • Clone
    Polyclonal
  • Antigen antibody binding interaction
    Rabbit anti HDAC1 Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Western Blot
  • Antibody s suited for
    Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -80ºC
  • Relevant references
    1: Dickson, R. C. (1998) Annu. Rev. Biochem. 67, 27Ð48_x000B_2: Pewzner-Jung, Y., Ben-Dor, S., and Futerman, A. H. (2006) J. Biol. Chem. 281, 25001Ð25005_x000B_3: Mandon, E. C., Ehses, I., Rother, J., van Echten, G., and Sandhoff, K. (1992) J. Biol. Chem. 267, 11144Ð11148_x000B_4: Jeckel, D., Karrenbauer, A., Burger, K. N., van Meer, G., and Wieland, F. (1992) J. Cell Biol. 117, 259Ð267_x000B_5: Futerman, A. H., Stieger, B., Hubbard, A. L., and Pagano, R. E. (1990) J. Biol. Chem. 265, 8650Ð8657_x000B_6: Huitema, K., van den Dikkenberg, J., Brouwers, J. F., and Holthuis, J. C. (2004) EMBO J. 23, 33Ð44_x000B_7: Yamaoka, S., Miyaji, M., Kitano, T., Umehara, H., and Okazaki, T. (2004) J. Biol. Chem. 279, 18688Ð18693_x000B_8: Ullman, M. D., and Radin, N. S. (1974) J. Biol. Chem. 249, 1506Ð1512_x000B_9: Voelker, D. R., and Kennedy, E. P. (1982) Biochemistry 21, 2753Ð2759_x000B_10: van Helvoort, A., van't Hof, W., Ritsema, T., Sandra, A., and van Meer, G. (1994) J. Biol. Chem. 269, 1763Ð1769_x000B_11: Muehlenberg, B. A., Sribney, M., and Duffe, M. K. (1972) Can J. Biochem. 50, 166Ð173_x000B_12: Hannun, Y. A., and Obeid, L. M. (2002) J. Biol. Chem. 277, 25847Ð25850_x000B_13: Wiegmann, K., Schutze, S., Machleidt, T., Witte, D., and Kronke, M. (1994) Cell 78, _x000B_Spiegel, S., and Milstien, S. (2003) Nat. Rev. Mol. Cell Biol. 4, 397Ð407_x000B_14: Ogretmen, B., and Hannun, Y. A. (2004) Nat. Rev. Cancer 4, 604Ð616_x000B_15: Holthuis, J. C., Pomorski, T., Raggers, R. J., Sprong, H., and Van Meer, G. (2001) Physiol. Rev. 81, 1689Ð1723
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • About
    Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • Gene target
    HDAC1  
  • Gene symbol
    HDAC1
  • Short name
    Rabbit anti HDAC1
  • Technique
    Rabbit, anti, antibody to
  • Host
    Rabbit, Rabbits
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    production species: rabbit antibody to histone deacetylase 1
  • Alternative technique
    rabbit-anti, antibodies
  • Alternative to gene target
    histone deacetylase 1, this GO N-10 and HD1 and RPD3 and RPD3L1, HDAC1 and IDBG-95712 and ENSG00000116478 and 3065, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, HDAC1 and IDBG-644586 and ENSBTAG00000012698 and 404126
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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