-
Category
Primary Antibodies
-
Long description
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as an HIV and SIV coreceptor1-4. Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.
-
Antibody come from
Antibody raised against a synthetic peptide corresponding to amino acids 11 to 25 of the human Bonzo protein. Peptide sequence differs from those of African green monkey and pig-tailed macaque by one or two amino acids, respectively.
-
Other description
Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative. Antigen Immunoaffiinity Purification
-
Clone
Polyclonal
-
Antigen antibody binding interaction
Rabbit anti CXCR6 (NT) Antibody
-
Antibody is raised in
Rabbit
-
Antibody s reacts with
Human
-
Antibody s reacts with these species
This antibody doesn't cross react with other species
-
Antibody s specificity
No Data Available
-
Application
Western Blot
-
Antibody s suited for
Detects Bonzo protein by Western blot at 0.5 to 1 µg/ml. Detects an approximately 45 kDa band in human spleen tissue lysate. Optimal concentration should be evaluated by serial dilutions.
-
Storage
-20ºC
-
Relevant references
1. Deng, H.K., et al. 'Expression cloning of new receptors used by simian and human immunodeficiency viruses.' Nature 1997, 388, 296-300 _x000B__x000B_2. Liao, F., et al. 'STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.' J. Exp. Med. 1997, 185, 2015-2023 _x000B__x000B_3. Alkhatib, G., et al. 'A new SIV co-receptor, STRL33.' Nature 1997, 388, 238 _x000B__x000B_4. Loetscher, M., et al. 'TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.' Curr. Biol. 1997, 7, 652-660_x000B_
-
Protein number
see ncbi
-
Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
-
About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin name
Oryctolagus cuniculus