Rabbit anti Adiponectin Receptor 2

• Catalog number
  X1699P
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  ADR2 functions as a receptor for globular and full-length adiponectin (APM1), which is an essential hormone secreted by adipocytes that acts as an antidiabetic. ADR2 is also probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. ADR2 mediates an increase in AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin and has some intermediate-affinity receptor activity for both globular and full-length adiponectin. ADR2 may form homo and heteromultimers.
• Antibody come from
  Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a peptide derived from the N-terminus of -smooth muscle actin and Sp 2/0 mouse myeloma cells. The epitope that is recognized by a-SM1 is Ac-EEED.
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Ammonium Sulfate Precipitation
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti Adiponectin Receptor 2 Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot, ELISA
• Antibody s suited for
  Antibody can be used for Western blotting (1:10,000-1:50,000), immunohistochemistry on paraffin-embedded or frozen tissues (1:1000-1:10,000), immunocytochemistry, immuno electron microscopy and ELISA. Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Skalli, O., et al. 'A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation. J Cell Biol 1986, 103, 2787-2796._x000B__x000B_2. Skalli, O., et al. 'Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins.' Lab Invest 1989, 60, 275-285._x000B__x000B_3. Sappino, A. P., et al. 'Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.' Lab Invest 1990, 63, 144-161._x000B__x000B_4. Vyalov, S. L., et al. Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis. Am J Pathol 1993 143, 1754-1765._x000B__x000B_5. Chaponnier, C., et al. The specific NH2-terminal sequence Ac-EEED of alpha-smooth_x000B_muscle actin plays a role in polymerization in vitro and in vivo. J Cell Biol 1995, 130, 887-895._x000B__x000B_6. Hinz, B., et al. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell 2001, 12, 2730-2741._x000B__x000B_7. Hinz, B., et al. 'The NH2-terminal peptide of alphasmooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo.' J Cell Biol 2002, 157, 657-663._x000B__x000B_8. Babaev, V.R., Bobryshev, Y.V., Stenina, O.V., Tararak, E.M. and Gabani, G. (1990). Heterogeneity of smooth musclein atheromatous plaque of human aorta. American Journal of Pathlogy 136, 1031-42._x000B__x000B_9. Simoncelli, F., Fagotti, A., Di Rosa, I., Panara, F., Chaponnier, C., Gabbiani, G., Pascolini, R., (1996). Expression of an actin in protochordates and lower craniates defined by anti- SM-1. European J of Cell Biol 69, 297-300._x000B__x000B_10. ClŽment, S., Hinz, B., Dugina, V., Gabbiani, G. and Chaponnier, C. (2004). The N-terminal Ac- EEED sequence plays a role in alpha-smooth- muscle actin incorporation into stress fibers. Journal of Cell Science 118, 1395-1404._x000B__x000B_11. Chaponnier, C. and Gabbiani, G. (2004). Pathological situation characterized by altered actin isoform expression. J Pathol 204, 386-95._x000B__x000B_12. ClŽment, S., Stouffs, M., Bettiol, E., Kampf, S., Krause, K., Chaponnier, C. and Jaconi, M. (2006). Expression and function of alpha- smooth muscle actin during embryonic-stem- cell-derived cardiomyocyte differentiation. Journal of Cell Science 120, 229-38._x000B__x000B_13. De Visscher, G., Plusquin, R., Mesure, L., Flameng, W. (2010). Selection of an immunohistochemical panel for cardiovascular research in sheep. Appl Immunohistochem Mol Morphol 18, 382-91.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  Adiponectin   Receptor  
• Gene symbol
  ADIPOR2, ADIPOR1P2
• Short name
  Rabbit anti Adiponectin Receptor 2
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to Adiponectin Receptor 2
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:24041
• Gene
  ADIPOR2
• Long gene name
  adiponectin receptor 2
• Synonyms
  • PAQR2
  • ACDCR2
• GenBank acession
  • AY424280
• Locus
  12p13.33
• Discovery year
  2004-06-23
• Entrez gene record
  79602
• Pubmed identfication
  • 12802337
• RefSeq identity
  • NM_024551
• Classification
  • Progestin and adipoQ receptor family
  • Adiponectin receptors
• VEGA ID
  OTTHUMG00000130139

Gene info

• Identity
  HGNC:44911
• Gene
  ADIPOR1P2
• Long gene name
  adiponectin receptor 1 pseudogene 2
• Locus
  14q32.13
• Discovery year
  2012-12-18
• Entrez gene record
  390503
• RefSeq identity
  • NG_022863
• VEGA ID
  OTTHUMG00000170861

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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