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Mouse Monoclonal IgG2a + IgG1 Basal Cell Marker Cocktail 1, p63 Protein + HMW Cytokeratin

  • Catalog number
    BAS001-G
  • Product name
    Mouse Monoclonal IgG2a + IgG1 Basal Cell Marker Cocktail 1, p63 Protein + HMW Cytokeratin
  • Size
    5 ml
  • Price
    308.09 USD
  • Supplier
  • Availability
    Please contact us to check the availability
  • Immunogen
    Recombinant human p63 protein (aa 1-205) and cytokeratin extract of human stratum corneum
  • Specificity
    nuclear p63 and cytoplasmic high molecular weight cytokeratins
  • Species reactivity
    Human
  • Product presentation
    Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for 250-500 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. Gentaur Art. No. PU002, if desired.
  • Product category
    Primary Antibodies
  • Antibody's raised in
    Mouse
  • Antibody's isotype
    IgG2a + IgG1
  • Antibody's clone
    4A4 + 34ßE12
  • Product is supplied as
    ready to use
  • Recommended concentration for use
    neat
  • Protein concentration
    See the included datasheet
  • Positive control
    Normal prostate tissue or skin
  • Pretreatment
    Use formalin-fixed and paraffin-embedded sections; Retrieval conditions: Unmasking fluid T, TEC buffer (Tris/EDTA/Citrate) pH 8 (Art. No. DE005) in a pressure cooker at 100°C 20-40 minutes
  • Tested applications
    IHC(P)
  • Recommended secondary reagent
    We recommend the use of Gentaur's Universal Staining System DAB (Art. No. DA005) or AEC (Art. No. AE005), but also other staining systems including anti-mouse IgG will be suitable
  • Storage method
    Store at 2-8°C
  • UniProt number
    Go to UniProt/SwissProt
  • Litterature
    1. Signoretti S., Waltregny D., Dilks J., Isaak B., Lin D., Garraway L., et al. (2000) p63 is a prostate basal cell marker and is required for prostate development. Am J. Pathol. 157; 1769-1775. 2. Weinstein M.H., Signoretti S., and Loda M. (2002) Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells. Mod. Pathol. 15(12); 1302-1308 3. Yang X.J., Lecksell K., Gaudin P., and Epstein J.I. (1999) Rare expression of high-molekular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer. Am. J. Surg. Pathol. 23(2); 147-152. 4. Browne TJ, Hirsch MS, Brodsky G, Welch WR, Loda MF, Rubin MA. Prospective evaluation of AMACR (P504S) and basal cell markers in the assessment of routine prostate needle biopsy specimens. Hum Pathol. 2004 Dec;35(12):1462-8. 5. Jiang Z, Li C, Fischer A, Dresser K, Woda BA. Using an AMACR (P504S)/34betaE12/p63 cocktail for the detection of small focal prostate carcinoma in needle biopsy specimens. Am J Clin Pathol. 2005 Feb;123(2):231-6.
  • Tips
    *Gentaur's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!
  • Description
    For cells, cell lines and tissues in culture till half confluency.
  • Additional isotype
    IgG1, IgG2a
  • About
    Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Gene target
  • Short name
    Mouse Monoclonal IgG2a + IgG1 Basal Cocktail 1, p63 Protein + HMW Cytokeratin
  • Technique
    Mouse monoclonal, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
  • Host
    mouse monoclonal, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
  • Species
    Mouse, Mouses
  • Alternative name
    Mouse monoclonal IgG2a and IgG1 Basal cellular detection labelled Cocktail 1, p63 Protein and HMW Cytokeratin
  • Alternative technique
    murine
1. Gene info
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