Mouse anti Interleukin 1alpha (IL-1alpha)

Catalog number

L124M
Price

Please ask
Size

500 μg

Category

Primary Antibodies
Long description

Interleukin 1 Receptor Antagonist inhibits the activity of IL-1 by binding to its receptor and has no IL-1 like activity._x000B__x000B_Genetic variation in IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis._x000B__x000B_Defects in IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA), also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis (bone inflammation in multiple places), periostitis (inflammation of the membrane surrounding the bones), and pustulosis (due to skin inflammation) from birth.
Antibody come from

n/a
Other description

Provided as sterile filtered solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein. Protein A/G Chromatography
Clone

AS8
Antigen antibody binding interaction

Mouse anti Interleukin 1alpha (IL-1alpha) Antibody
Antibody is raised in

Mouse
Antibody s reacts with

Human
Antibody s reacts with these species

This antibody doesn't cross react with other species
Antibody s specificity

No Data Available
Application

ELISA
Antibody s suited for

Optimal concentration should be evaluated by serial dilutions. This antibody has been used at 10 µl per test (10^5-10^6 cells) to stain intracellular human IL-1RA expressed in Brefeldin A-treated monocytes and macrophages.
Storage

-20ºC
Relevant references

no information yet
Protein number

see ncbi
Warnings

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Antibody s link
Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name

Mus musculus

Gene target

Interleukin 1alpha IL-1alpha
Gene symbol

IL36G, IL25, IL22, IL18, IL37, IL6R, IL17C, IL17A, IL17D, IL31
Short name

Mouse anti Interleukin 1alpha (IL-1alpha)
Technique

Mouse, anti, antibody to, mouses
Host

mouse
Isotype

IgG1
Label

unlabeled
Species

Mouse, Mouses
Alternative name

Mouse antibody to Interleukin 1alpha (Interleukin-1alpha)
Alternative technique

murine, antibodies

Gene info

Identity

HGNC:15741
Gene

IL36G
Long gene name

interleukin 36 gamma
Synonyms gene
- IL1F9
Synonyms gene name
- interleukin 1 family, member 9
Synonyms
- IL-1H1
- IL-1RP2
- IL-1F9
- IL1H1
- IL1E
Synonyms name
GenBank acession
- AF200492
Locus

2q14.1
Discovery year

2002-08-02
Entrez gene record

56300
Pubmed identfication
- 10860666
- 10744718
- 11991722
- 11991723
RefSeq identity
- NM_019618
Classification
- Interleukins
VEGA ID

OTTHUMG00000131336

Gene info

Identity

HGNC:13765
Gene

IL25
Long gene name

interleukin 25
Synonyms gene
- IL17E
Synonyms gene name
- interleukin 17E
Synonyms
- IL-25
- IL-17E
GenBank acession
- AF305200
Locus

14q11.2
Discovery year

2001-01-26
Pubmed identfication
- 11058597
- 11754819
Classification
- Interleukins
VEGA ID

OTTHUMG00000028749

Gene info

Identity

HGNC:14900
Gene

IL22
Long gene name

interleukin 22
Synonyms
- ILTIF
- IL-21
- zcyto18
- IL-TIF
- IL-D110
- TIFa
- TIFIL-23
- IL-22
- MGC79382
- MGC79384
Synonyms name
- IL-10-related T-cell-derived inducible factor
GenBank acession
- AF279437
Locus

12q15
Discovery year

2001-03-12
Entrez gene record

50616
Pubmed identfication
- 10954742
- 10875937
RefSeq identity
- NM_020525
Classification
- Interleukins
VEGA ID

OTTHUMG00000169119
Locus Specific Databases
- LRG_1248

Gene info

Identity

HGNC:5986
Gene

IL18
Long gene name

interleukin 18
Synonyms gene name
- interleukin 18 (interferon-gamma-inducing factor)
Synonyms
- IGIF
- IL1F4
- IL-1g
- IL-18
Synonyms name
- interferon-gamma-inducing factor
GenBank acession
- U90434
Locus

11q23.1
Discovery year

1997-07-25
Entrez gene record

3606
Pubmed identfication
- 7477296
- 9693051
RefSeq identity
- NM_001562
Classification
- Interleukins
VEGA ID

OTTHUMG00000167006

Gene info

Identity

HGNC:15563
Gene

IL37
Long gene name

interleukin 37
Synonyms gene
- IL1F7
Synonyms gene name
- interleukin 1 family, member 7 (zeta)
Synonyms
- FIL1
- FIL1Z
- FIL1(ZETA)
- IL-1H4
- IL-1RP1
- IL-1F7
Synonyms name
GenBank acession
- AF201832
Locus

2q14.1
Discovery year

2002-08-02
Entrez gene record

27178
Pubmed identfication
RefSeq identity
- NM_014439
Classification
- Interleukins
VEGA ID

OTTHUMG00000131345

Gene info

Identity

HGNC:6019
Gene

IL6R
Long gene name

interleukin 6 receptor
Synonyms
- CD126
- IL-6R
- IL-1Ra
- IL6RA
- gp80
Synonyms name
- membrane glycoprotein 80
- interleukin 6 receptor subunit alpha
GenBank acession
- X12830
Locus

1q21.3
Discovery year

2001-06-22
Entrez gene record

3570
Pubmed identfication
- 8428753
- 12633863
RefSeq identity
- NM_000565
Classification
- CD molecules
- Interleukin receptors
- Immunoglobulin like domain containing
VEGA ID

OTTHUMG00000036073

Gene info

Identity

HGNC:5983
Gene

IL17C
Long gene name

interleukin 17C
Synonyms
- IL-17C
- CX2
- IL-21
- MGC126884
- MGC138401
GenBank acession
- AF152099
Locus

16q24.2
Discovery year

2000-01-20
Entrez gene record

27189
Pubmed identfication
- 10639155
RefSeq identity
- NM_013278
Classification
- Interleukins
VEGA ID

OTTHUMG00000173241

Gene info

Identity

HGNC:5981
Gene

IL17A
Long gene name

interleukin 17A
Synonyms gene
- CTLA8
- IL17
Synonyms gene name
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Synonyms
- IL-17A
- IL-17
Synonyms name
- cytotoxic T-lymphocyte-associated protein 8
GenBank acession
- U32659
Locus

6p12.2
Discovery year

1993-10-25
Entrez gene record

3605
Pubmed identfication
- 8390535
RefSeq identity
- NM_002190
Classification
- Interleukins
VEGA ID

OTTHUMG00000014840
Locus Specific Databases
- LRG_1223

Gene info

Identity

HGNC:5984
Gene

IL17D
Long gene name

interleukin 17D
Synonyms
- IL-27
- IL-17D
- IL27
- FLJ30846
Synonyms name
- interleukin 27
GenBank acession
- AY078238
Locus

13q12.11
Discovery year

2000-05-02
Entrez gene record

53342
Pubmed identfication
- 12097364
RefSeq identity
- NM_138284
Classification
- Interleukins
VEGA ID

OTTHUMG00000016521

Gene info

Identity

HGNC:19372
Gene

IL31
Long gene name

interleukin 31
Synonyms
- IL-31
GenBank acession
- AY499343
Locus

12q24.31
Discovery year

2003-11-06
Entrez gene record

386653
Pubmed identfication
- 15184896
RefSeq identity
- NM_001014336
Classification
- Interleukins
VEGA ID

OTTHUMG00000168916

MeSH Data

Name

Blotting, Western
Concept

Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Mouse anti Interleukin 1alpha (IL-1alpha)

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

Gene info

MeSH Data

Product images

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