Mouse anti Human HLA DQ

  • Catalog number
    MUB2014S
  • Product name
    Mouse anti Human HLA DQ
  • Size
    1 mL
  • Price
    249.11
  • Supplier
    nordc
  • Category
    Primary Antibodies
  • Long description
    HLA-DQ (DQ) is a cell surface receptor type protein found on antigen presenting cells. DQ is an αβ heterodimer of the MHC Class II type. The α and β chains are encoded by HLA-DQA1 and HLA-DQB1, respectively. These two loci are adjacent to each other on chromosome 6p21.3. Both the α-chain and β-chain vary greatly. A person often produces two α-chain and two β-chain variants and thus 4 DQ isoforms. The DQ loci are in close genetic linkage to HLA-DR but less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. DQ functions on antigen presenting cells, and is an antigen presenting molecule. Different DQ isoforms can bind to and present different antigens to T-cells. In this process T-cells are stimulated to grow and can signal B-cells to produce antibodies. DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age. When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. DQ is one of several antigens involved in rejection of organ transplants. As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft versus host disease when lymphoid tissues are transplanted between people.
  • Antibody come from
    n/a
  • Other description
    Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.
  • Clone
    NKI(SPV)L3
  • Antigen-antibody binding interaction
    Mouse anti Human HLA DQ Antibody
  • Antibody is raised in
    Mouse (Balb/c)
  • Antibody's reacts with
    Human,Swine
  • Antibody's reacts with these species
    This antibody doesn't cross react with other species
  • Antibody's specificity
    NKI(SPV)L3 reacts with a monomorphic determinant on HLA-DQ (MHC class II).
  • Research interest
    Immunology
  • Application
    Flow Cytometry,Immunohistochemistry (frozen),Immunoprecipitation
  • Antibody's suited for
    NKI(SPV)L3 is used in research and Human diagnostics, cell sepaRation for research or clinical appliCation. NKI(SPV)L3 is useful for immunoprecipitation, flow cytometry and immunohistochemsitry on frozen sections. Optimal antibody dilution should be determined by titration.
  • Storage
    Store at 4°C, or in small aliquots at –20°C.
  • Relevant references
    Spits H., G. Keizer, J. Borst, C. Terhorst, A. Hekman and J.E. de Vries. Characterization of monoclonal antibodies anti cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma 1983, 4: 423-437. Spits H., J. Borst, M. Giphart, J. Coligan, C. Terhorst and J.E. de Vries. HLA-DC antigens can serve as recognition elements for Human cytotoxic T lymphocytes. Eur. J. Immunol. 1984, 14: 299. A.A. te Velde, J.P.G. Klomp, B.A. Yard, J.E. de Vries, C.G. Figdor. Modulation of phenotypic and functional properties of Human peripheral blood monocytes by IL-4. J. of Immunol. 1988, 140: 1548-1554.
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • group_crc32
    1841684386
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • Gene target
    HLA DQ 
  • Short name
    Mouse anti HLA DQ
  • Technique
    anti human, antibody to, anti human antibodies, mouses
  • Host
    mouse
  • Species
    Human, Humans, Mouses
  • Alternative name
    Mouse antibody to H. sapiens Human leukocyte antigen DQ
  • Alternative technique
    murine
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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Mouse anti Human HLA DQ - Gentaur.com
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