PAb (IgG) to Sheep SFN / Stratifin / 14-3-3 Sigma

  • Catalog number
    MBS244926
  • Price
    Please ask
  • Size
    0.05 ml
  • Alternative name1
    Anti-Rabbit Polyclonal (IgG) to Sheep SFN / Stratifin / 14-3-3 Sigma
  • Alternative name2
    Rabbit PAb (IgG) to Ovine SFN / Stratifin / 14-3-3 Sigma
  • Alternative name3
    Lapin Polyclonal (IgG) to Ovinae SFN / StRattus norvegicusifin / 14-3-3 Sigma
  • Alternative name4
    SFN / Stratifin / 14-3-3 Sigma
  • Alternative name5
    Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (N-Terminus) IHC-plus; SFN; 14-3-3 sigma; 14-3-3 protein sigma; HME1; Stratifin; YWHAS; Sheep SFN; Stratifin; 14-3-3 Sigma
  • Other names
    14-3-3 protein sigma; 14-3-3 protein sigma; 14-3-3 protein sigma; 14-3-3 sigma; epithelial cell marker protein 1; stratifin; Epithelial cell marker protein 1; Stratifin
  • Gene name
    SFN
  • Gene name synonims
    N/A
  • Other gene names
    SFN; SFN; YWHAS; HME1
  • Category
    Antibodies
  • Clonality
    Polyclonal
  • Immunoglobulin isotype
    IgG
  • Clone
    Polyclonal antibody
  • Host organism
    Rabbit
  • Species reactivity
    Bovine, Chicken, Human, Mouse, Rabbit, Rat, Sheep Predicted Reactivity: Mammal (at least 90% immunogen sequence identity)
  • Specificity and cross reactivity
    Recognizes 14-3-3 sigma in all mammals. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 sigma is expressed mostly in epithelial cells and has been associated with cancers including breast, nasopharyngeal, endometrial adenocarcinoma, prostate, epithelial ovarian, colorectal, adenoid cystic, and papillary. 14-3-3 sigma binds c-fos activating the MAPK pathway. Sequestration of Bax by 14-3-3 sigma inhibits apoptosis whereas sequestration of 14-3-3 sigma by CARP-1 induces it. Mitosis is regulated by 14-3-3 sigma through binding keratin filaments and sequestering cyclin B1 and cdc2. p73-dependent induction of 14-3-3 sigma regulates chemo sensitivity in breast cancers with p53 mutations. In reaction to DNA damage and along with RACK1, 14-3-3 sigma targets, DeltaNp63alpha for proteasome degradation. 14-3-3 also negatively regulates both the glucocorticoid receptor and the activity of PKB/Akt which stabilizes p27 Kip1. May not react with recombinant proteins that are not N-acetylated.
  • Purification method
    N/A
  • Form Appearance
    Serum, 0.09% sodium azide.
  • Concentration
    N/A
  • Storage and shipping
    Long term: Store productone at -20 degrees Celsius.; Short term: +Store productone at +4 degrees Celsius.. Avoid repeat freeze-thaw cycles.
  • Tested for
    Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
  • Description
    productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
  • Advisory
    In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • About
    Immunoglobulin gamma, IgG, mouse monoclonal H&L chain clones or rabbit, goat polyclonal antibodies have 4 parts. There are 2 heavy chains, 2 light chains. The IgG antibody has 2 antigen binding sites. They represent 70% or more of serum antibodies. This antibody can be antigen purified or protein A or G purified. For storage sodium azide is added or you can call us to request azide free antibody preparations. These will need colder storage temperatures.
  • Gene target
    PAb   SFN   Stratifin   14-3-3   Sigma  
  • Gene symbol
    YWHAQ, YWHAG, YWHAZ, MIR1302-3, MIR509-3, MIR7-3, PIRC14, PIRC12
  • Short name
    PAb (IgG) SFN / Stratifin / 14-3-3 Sigma
  • Technique
    IgG, IgGs
  • Host
    Sheep
  • Isotype
    IgG, IgG
  • Species
    Sheep, The sheep (Ovis aries) ELISAs are detecting sheep proteins and antigens. Some epitopes will also recognize goat proteins. Sheep and goats are also used to produce polyclonals. An adult female sheep is referred to as a ewe a male as a ram, a castrated male as a wether, and a younger sheep as a lamb. Sheeps
  • Alternative name
    polyclonal (Immunoglobulin G) to ovine stratifin / Stratifin / 14-3-3 Sigma
  • Alternative technique
    immunoglobulins
  • Alternative to gene target
    stratifin, YWHAS, SFN and IDBG-94738 and ENSG00000175793 and 2810, phosphoprotein binding, nuclei, Sfn and IDBG-195282 and ENSMUSG00000047281 and 55948, SFN and IDBG-647781 and ENSBTAG00000009223 and 528453
Gene info
  • Identity
  • Gene
  • Long gene name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  • Synonyms gene name
    • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
    • protein, theta
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1999-08-20
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • 14-3-3 phospho-serine/phospho-threonine binding proteins
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  • Synonyms gene
  • Synonyms gene name
    • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
    • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1993-09-20
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • 14-3-3 phospho-serine/phospho-threonine binding proteins
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 14
  • Locus
    3
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Gene info
  • Identity
  • Gene
  • Long gene name
    piwi-interacting RNA cluster 12
  • Locus
    3
  • Discovery year
    2009-11-05
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Piwi-interacting RNA clusters
Product images
Similar products
Filters
Contact
Chat with gentaur.com employee