Apigenin, Protein kinase inhibitor

  • Catalog number
    SIH-249-10MG
  • Price
    Please ask
  • Size
    10 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    520-36-5
  • Description
    Protein kinase inhibitor
  • Molecular weight
    270,2 g/mol
  • Primary research fields
    Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
  • Other name
    5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C15H10O5
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    Soluble to 50 mM in DMSO
  • Physical appearance
    White Solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68 - Possible risk of irreversible effects
  • PubChem number
    5280443
  • Scientific context
    Apigenin induces a process called autophagia (1). It is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body (2). Apigenin has also been shown to reverse the adverse effects of cyclosporine (3).
  • Bibliography
    1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11. 2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634. 3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.
  • Release date
    16-May-2011
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Apigenin (SIH-249), a Protein kinase inhibitor. CAS #: 520-36-5. Molecular Formula: C15H10O5. Molecular Weight: 270.2 g/mol. Chemical structure of Apigenin, a Protein kinase inhibitor (SIH-249). CAS # 520-36-5. Molecular Formula: C15H10O5.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.01
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    Apigenin, Protein kinase inhibitor
  • Alternative name
    Apigenin, Protein phosphorylation catalyst suppressor
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