Apigenin, Protein kinase inhibitor
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Catalog number
SIH-249-10MG
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Price
Please ask
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Size
10 mg
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Stock availabilitIn Stock
In Stock
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CAS number
520-36-5
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Description
Protein kinase inhibitor
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Molecular weight
270,2 g/mol
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Primary research fields
Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C15H10O5
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble to 50 mM in DMSO
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Physical appearance
White Solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68 - Possible risk of irreversible effects
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PubChem number
5280443
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Scientific context
Apigenin induces a process called autophagia (1). It is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body (2). Apigenin has also been shown to reverse the adverse effects of cyclosporine (3).
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Bibliography
1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11. 2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634. 3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.
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Release date
16-May-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Apigenin (SIH-249), a Protein kinase inhibitor. CAS #: 520-36-5. Molecular Formula: C15H10O5. Molecular Weight: 270.2 g/mol. Chemical structure of Apigenin, a Protein kinase inhibitor (SIH-249). CAS # 520-36-5. Molecular Formula: C15H10O5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Apigenin, Protein kinase inhibitor
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Alternative name
Apigenin, Protein phosphorylation catalyst suppressor
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