Recombinant Human Membrane Primary Amine Oxidase/AOC3 Protein(C-6His)
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Catalog number
PKSH032744-10µg
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Price
Please ask
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Size
10µg
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Synonym
Membrane primary amine oxidase; Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1; AOC3; VAP1
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Activity
NA
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Sequence
Arg27-Asn763
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Fusion tag
C-6His
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Accession
Q16853
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Expressed Host
Human cells
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Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity
＞95% as determined by reducing SDS-PAGE.
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Endotoxin
＜1.0 EU per µg as determined by LAL test.
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Stability and Storage
Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
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Mol Mass
82.6 kDa
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AP Mol Mass
64 kDa
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Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, pH8.0 .
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Background
Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inflammation through its release from intracellular granules in which the protein is stored. The adhesive function of VAP-1 has been demonstrated in studies showing that the protein is important for the adherence of certain lymphocyte subtypes to inflamed endothelial tissues. VAP-1 mediated adhesion is involved in the process of leukocyte extravasation, an important feature of inflammatory responses. VAP-1 is considered to be a therapeutic target for diabetes, oxidative stress, and inflammatory diseases.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Description
Associated membrane protein types are lipopolysaccharide selective barriers. Biological membranes include cell membranes, outer coverings of cells or organelles that allow passage of certain proteins and nuclear membranes, which cover a cell nucleus; and tissue membranes, such as mucosae and serosae.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
AOC3
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Short name
Recombinant Primary Amine Oxidase/AOC3 Protein(C-6His)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens Membrane captor Amine Oxidase/amine oxidase, copper containing 3 (vascular adhesion protein 1) Protein(C-6His)
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Alternative technique
rec
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Alternative to gene target
amine oxidase, copper containing 3 (vascular adhesion protein 1), HPAO and SSAO and VAP-1 and VAP1, AOC3 and IDBG-51885 and ENSG00000131471 and 8639, oxygen oxidoreductase (deaminating) activity, Cell surfaces, Aoc3 and IDBG-212089 and ENSMUSG00000019326 and 11754, LOC100336124 and IDBG-640496 and ENSBTAG00000046264 and
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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