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Alternative name 1
CD115, c-fms, CSF-1R, Macrophage Colony Stimulating Factor Receptor (M-CSFR), Clone: 2-4A5-4, Rat Mab anti-Human, No X w/Mouse or Cat; frozen, IH/Blocking/Inhibits
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Alternative name 2
CD115, c-fms, CSF-1R, Macrophage Colony Stimulating Factor Receptor (M-CSFR), Clone: 2-4A5-4, Rat Mab antibody-Human, No X w/Mouse or Cat; frozen, IH/Blocking/Inhibits
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Alternative name 3
CD115, c-fms, CSF-1R, Macrophage Colony Stimulating Factor Receptor (M-CSFR), Clone: 2-4A5-4, Rattus norvegicus Mab antibody-Homo sapiens, No X w/Mus musculus or Cat; frozen, IH/Blocking/Inhibits
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Alternative name 4
anti-CD115 c-fms CSF-1R Macrophage Colony Stimulating Factor Receptor M-CSFR Clone: 2-4A5-4 No X w/ or Cat Blocking/Inhibits
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Alternative name 5
CD115 c-fms CSF-1R Macrophage Colony Stimulating Factor Receptor M-CSFR Clone: 2-4A5-4 No X w/ or Cat Blocking/Inhibits
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Clonality
Monoclonal Antibody
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Description
This is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against. If used correctly and according the protocol, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications. Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches; in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required.
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Storage and handling
Generally, antibodies that are lyophilized can be transported at ambient temperature and stored for short terms at +4 degrees Celsius, for longer periods - at -20 . Antibodies in a liquid form can be shipped and stored for a short period of time at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol should be added and then the container has to be stored at -20°C.
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Advisory
To keep the quality and the affinity of the antibody cycles of freezing and thawing should be avoided. For antibodies in a liquid form or reconstituted lyophilized antibodies small amounts of the soultion could be captured on the cap or the walls of the container. Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom.
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Properties
If you buy Antibodies supplied by accurate-monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Felix vulgaris genes or proteins used as antigen, synthetic peptide. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Test
You can block the antibody by the specific target amino acid sequence of peptide. Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Additional description
Colonies can be formed by stimulating factors or recombinant GM-CSF and CSFs activity expressed in Units compared to a standard. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes. Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin name
Mus musculus, Rattus norvegicus
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French translation
anticorps
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Gene target
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Gene symbol
CSF1R, CSF1, CPT1B, GLP1R, CDK2AP2, TRL-AAG2-4, MIR3130-2, TRP-AGG2-4, TRG-TCC2-4, TRD-GTC2-4
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Short name
CD115, c-fms, CSF-1R, Macrophage Colony Stimulating Factor Receptor (M-CSFR), Clone: 2-4A5-4, Mouse Monoclonal antibody- , No X w/Mouse Cat; frozen, IH/Blocking/Inhibits
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Technique
Mouse monoclonal, Antibody, Blocking, frozen, Mouse, antibodies against human proteins, antibodies for, blocking peptides, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Rat, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Species
Cat, Cats, Humans, Mouses, Rats
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Alternative name
CD115, c-fms, CSF-1R, Macrophage Colony Stimulating Factor Receptor (M-CSFR), clonality: 2-4A5-4, Rat Mouse monoclonal (antibody to-)-H. sapiens, No X w/Mouse and catalase; -25°C frozen, IH/inhibiting/Inhibits
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Alternative technique
control, antibodies, murine
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Alternative to gene target
catalase, CAT and IDBG-39262 and ENSG00000121691 and 847, oxidoreductase activity, Plasma membranes, Cat and IDBG-193911 and ENSMUSG00000027187 and 12359, CAT and IDBG-636518 and ENSBTAG00000020980 and 531682
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Tissue
frozen
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