Rat anti Interleukin-4 (Neutralizing)

• Catalog number
  X1934M
• Price
  Please ask
• Size
  500 μg

• Category
  Primary Antibodies
• Long description
  IL4 participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
• Antibody come from
  Recombinant human MEK1 protein.
• Other description
  Provided as solution in phosphate buffered saline, pH 7.3, with 1% BSA and 0.08% sodium azide. Protein A/G Chromatography
• Clone
  BVD4-1D11
• Antigen antibody binding interaction
  Rat anti Interleukin-4 (Neutralizing) Antibody
• Antibody is raised in
  Rat
• Antibody s reacts with
  Mouse
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  ELISA, as a coating antibody
• Antibody s suited for
  Antibody can be used for Western blotting (0.5-1 µg/ml). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Kolch, W., et al. (2000) Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351:289-305._x000B__x000B_2. Slack-Davis, J.K., et al. (2003) PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. Cell Biol. 162(2):281-291._x000B__x000B_3. Whitmarsh, A.J. and R.J. Davis (1998) Structural organization of MAP-kinase signaling modulates by scaffold proteins in yeast and mammals. Trends Biochem. Sci. 23:481-485._x000B__x000B_4. Whitmarsh, A.J. and R.J. Davis (1999) Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches. Science's STKE www.stke.org/cgi/content/full/ OC_ sigtrans; 1999/1/pe1._x000B__x000B_5. Widman, C., et al. (1999) Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human. Physiol. Rev. 79:143-180.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  To cause (an acid or base) to undergo neutralization.
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus

• Gene target
  Interleukin-4  
• Gene symbol
  IL4R, IL9RP4, IL4I1
• Short name
  anti Interleukin-4 ( )
• Technique
  anti, antibody to
• Host
  Rat
• Isotype
  IgG2b
• Label
  unlabeled
• Species
  Rat, Rats
• Alternative name
  Rat antibody to Interleukin-4 (Neutralizing)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6015
• Gene
  IL4R
• Long gene name
  interleukin 4 receptor
• Synonyms
  • CD124
• Synonyms name
  • interleukin 13 receptor
• GenBank acession
  • X52425
• Locus
  16p12.1
• Discovery year
  1990-07-06
• Entrez gene record
  3566
• Pubmed identfication
  • 1679753
• Classification
  • Interleukin receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000097015

Gene info

• Identity
  HGNC:6034
• Gene
  IL9RP4
• Long gene name
  interleukin 9 receptor pseudogene 4
• Locus
  18p11.32
• Discovery year
  1995-11-01
• Entrez gene record
  100132166
• Pubmed identfication
  • 8666384
• RefSeq identity
  • NG_002764
• VEGA ID
  OTTHUMG00000177934

Gene info

• Identity
  HGNC:19094
• Gene
  IL4I1
• Long gene name
  interleukin 4 induced 1
• Synonyms
  • FIG1
• GenBank acession
  • AF293462
• Locus
  19q13.33
• Discovery year
  2002-08-20
• Entrez gene record
  259307
• Pubmed identfication
  • 12031486
• VEGA ID
  OTTHUMG00000183377

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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