Rat anti Interleukin-4 (Neutralizing)
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Catalog numberX1934M
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PricePlease ask
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Size500 μg
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CategoryPrimary Antibodies
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Long descriptionIL4 participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
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Antibody come fromRecombinant human MEK1 protein.
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Other descriptionProvided as solution in phosphate buffered saline, pH 7.3, with 1% BSA and 0.08% sodium azide. Protein A/G Chromatography
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CloneBVD4-1D11
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Antigen antibody binding interactionRat anti Interleukin-4 (Neutralizing) Antibody
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Antibody is raised inRat
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Antibody s reacts withMouse
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationELISA, as a coating antibody
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Antibody s suited forAntibody can be used for Western blotting (0.5-1 µg/ml). Optimal concentration should be evaluated by serial dilutions.
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Storage-20ºC
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Relevant references1. Kolch, W., et al. (2000) Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351:289-305._x000B__x000B_2. Slack-Davis, J.K., et al. (2003) PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. Cell Biol. 162(2):281-291._x000B__x000B_3. Whitmarsh, A.J. and R.J. Davis (1998) Structural organization of MAP-kinase signaling modulates by scaffold proteins in yeast and mammals. Trends Biochem. Sci. 23:481-485._x000B__x000B_4. Whitmarsh, A.J. and R.J. Davis (1999) Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches. Science's STKE www.stke.org/cgi/content/full/ OC_ sigtrans; 1999/1/pe1._x000B__x000B_5. Widman, C., et al. (1999) Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human. Physiol. Rev. 79:143-180.
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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TestTo cause (an acid or base) to undergo neutralization.
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AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin nameRattus norvegicus
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Gene target
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Gene symbolIL4R, IL9RP4, IL4I1
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Short nameanti Interleukin-4 ( )
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Techniqueanti, antibody to
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HostRat
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IsotypeIgG2b
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Labelunlabeled
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SpeciesRat, Rats
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Alternative nameRat antibody to Interleukin-4 (Neutralizing)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameinterleukin 4 receptor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-07-06
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Entrez gene record
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Pubmed identfication
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Classification
- Interleukin receptors
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 9 receptor pseudogene 4
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Locus
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Discovery year1995-11-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 4 induced 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-08-20
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Entrez gene record
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Pubmed identfication
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data