RAT ANTI MOUSE TIM-4:Low Endotoxin Antibody
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Catalog numberGEN224713
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PricePlease ask
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Size500ug
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Also known asTIM-4
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Other namesT-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin and mucin domain-containing protein 4; TIMD-4; smuckler; T-cell membrane protein 4; T-cell immunoglobulin and mucin domain containing 4; spleen, mucin-containing, knockout of lymphotoxin protein; T cell immunoglobulin and mucin domain containing 4; Spleen, mucin-containing, knockout of lymphotoxin protein; SMUCKLER; T-cell membrane protein 4; TIM-4
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CategoryAntibodies
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SubcategoryMnoclonal antibodies
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Gene nameTIM-4
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Gene name synonimsN/A
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Other gene namesTimd4; Timd4; Tim4; TIM-4; B430010N18Rik; Tim4; TIMD-4; SMUCKLER
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ClonalityMonoclonal
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Immunoglobulin isotypeIgG2a
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CloneRMT4-54
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Host organismRat (Rattus norvegicus)
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Species reactivityMouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivityTIM-4 Clone RMT4-54 specifically recognises mouse Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production. _x000D__x000D_Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma. _x000D__x000D_Studies have shown that clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) _x000D__x000D_; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification methodN/A
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Form AppearanceLow Endotoxin (Purified IgG - liquid)
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ConcentrationIgG concentration 1.0mg/ml
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Storage and shippingStore the antibody should be stored at -20 degrees Celsius. only. Storage in frost-free freezers is not recommended. the antibody should be stored undiluted. Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 18 months from date of dispatch.
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Tested applicationsFunctional Assay (FA), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistology - Paraffin (IHC)
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
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PropertiesIf you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin nameMus musculus, Rattus norvegicus
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AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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French translationanticorps
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Gene target
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Gene symbolTIMD4, TIMELESS, ARHGEF5, MIR1302-4, PIRC18, PIRC16, SNORD114-4, IGKV2OR2-4
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Short nameANTI MOUSE TIM-4: Endotoxin Antibody
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Techniqueanti mouse, Antibody, Mouse, anti, antibody to, anti mouse antibodies, antibodies against human proteins, antibodies for, mouses
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HostRat
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SpeciesMouse, Mouses, Rats
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Alternative nameAnti-RAT ANTI MOUSE TIM-4:Low Endotoxin
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Alternative techniqueantibodies, murine
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Gene info
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Identity
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Gene
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Long gene nameT cell immunoglobulin and mucin domain containing 4
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Synonyms gene name
- T-cell immunoglobulin and mucin domain containing 4
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-07-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametimeless circadian regulator
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Synonyms gene name
- timeless (Drosophila) homolog
- timeless homolog (Drosophila)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-01-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRho guanine nucleotide exchange factor 5
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Synonyms gene name
- Rho guanine nucleotide exchange factor (GEF) 5
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-02-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Dbl family Rho GEFs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1302-4
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1302 family
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 18
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namepiwi-interacting RNA cluster 16
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Locus
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Discovery year2009-11-05
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Entrez gene record
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Pubmed identfication
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Classification
- Piwi-interacting RNA clusters
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, C/D box 114-4
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Synonyms
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Locus
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Discovery year2006-09-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, C/D box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin kappa variable 2/OR2-4 (pseudogene)
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Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-04-18
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Entrez gene record
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Pubmed identfication
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Classification
- Immunoglobulin kappa (IGK) orphons
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
