HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 1:RPE Antibody

  • Catalog number
    GEN224679
  • Price
    Please ask
  • Size
    100 Tests
  • Also known as
    DELTA-LIKE PROTEIN 1
  • Other names
    delta-like protein 1; Delta-like protein 1; delta-like protein 1; H-Delta-1; drosophila Delta homolog 1; delta-like 1 (Drosophila); Drosophila Delta homolog 1
  • Category
    Antibodies
  • Subcategory
    Mnoclonal antibodies
  • Gene name
    DLL1; DLL1; DL1; Delta; DELTA1; Delta1; H-Delta-1
  • Gene name synonims
    DLL1; DLL1; DL1; Delta; DELTA1; Delta1; H-Delta-1
  • Other gene names
    DLL1; DLL1; DL1; Delta; DELTA1; Delta1; H-Delta-1
  • Clonality
    Monoclonal
  • Immunoglobulin isotype
    IgG
  • Clone
    HMD1-5
  • Host organism
    Hamster
  • Species reactivity
    Mouse (Mus musculus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
  • Specificity and cross reactivity
    DELTA-LIKE PROTEIN 1 This item specifically recognises Delta-like protein 1 (DLL1), one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumour progression and suppression. _x000D__x000D_Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. _x000D__x000D_DLL1 is widely expressed, and acts as a mediator of cell fate decisions during hematopoiesis, and may play a role in cell-to-cell communication in mammalian embryos. DLL1 plays an important role in B and T cell differentiation, in embryonic somite formation and patterning, and associates with the scaffolding protein MAGI1 at adherens junctions on neuronal processes. Signalling through DLL1 and Notch 2 has been implicated in the development of marginal zone B cells (MZB). _x000D__x000D_Clone HMD1-5 has been shown to cross-react with rat mast cell line RBL-2H3 in flow cytometry.
  • Purification method
    N/A
  • Form Appearance
    RPE (Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised)
  • Concentration
    N/A
  • Storage and shipping
    Prior to reconstitution Keep the antibody refrigerated at +4 degrees Celsius. Temperature variations in the range between +1C to +7C are tolerable. After reconstitution Keep the antibody refrigerated at +4 degrees Celsius. Temperature variations in the range between +1C to +7C are tolerable. DO NOT FREEZE. the antibody should be stored undiluted. the antibody is photosensitive and should be protected from light. If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use. Shelf Life: 12 months from date of reconstitution
  • Tested applications
    Flow Cytometry (FACS)
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
  • Properties
    If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Armenian of Syrian hamster monoclonal IgGs are useful antibodies for double staining your IHC samples. Using mabs or monoclonal antibodies has a lot of advantages for Flow cytometry.
  • Test
    Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
  • Latin name
    Mus musculus
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    RPE, AGPAT4, PSMB6, AHCTF1P1, PPM1D, INGX, PSMA6P1, AFF3, LPAR4, TFDP3
  • Short name
    ANTI MOUSE DELTA-LIKE PROTEIN 1:RPE Antibody
  • Technique
    anti mouse, Antibody, Mouse, anti, antibody to, anti mouse antibodies, antibodies against human proteins, antibodies for, mouses
  • Host
    Hamster
  • Label
    rpe
  • Species
    Mouse, Hamsters, Mouses
  • Alternative name
    Anti-HAMSTER ANTI MOUSE DELTA-LIKE PROTEIN 1:RPE
  • Alternative technique
    antibodies, murine
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    AT-hook containing transcription factor 1 pseudogene 1
  • Synonyms gene
  • Synonyms gene name
    • AT hook containing transcription factor 1 pseudogene
    • AT hook containing transcription factor 1 pseudogene 1
  • Synonyms
  • Locus
  • Discovery year
    2005-06-20
  • Entrez gene record
  • RefSeq identity
Gene info
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    AF4/FMR2 family member 3
  • Synonyms gene
  • Synonyms gene name
    • lymphoid nuclear protein related to AF4
    • AF4/FMR2 family, member 3
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1998-03-27
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Super elongation complex
    • AF4/FMR2 family
  • VEGA ID
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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