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Alternative name1
Anti-RABBIT ANTI MOUSE BLNK
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Alternative name2
RABBIT ANTI Murine BLNK
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Alternative name3
Lapin ANTI Mus musculus BLNK
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Alternative name4
BLNK
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Alternative name5
N/A
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Other names
B-cell linker protein; B-cell linker protein; B-cell linker protein; lymphocyte antigen 57; cytoplasmic adapter protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; src homology 2 domain-containing leukocyte protein of 65 kDa; B cell linker; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Lymphocyte antigen 57; Src homology 2 domain-containing leukocyte protein of 65 kDa
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Gene name
BLNK
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Gene name synonims
N/A
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Other gene names
Blnk; Blnk; Bca; BASH; Ly57; Ly-57; Lyw-57; SLP-65; Bash; Ly57; Slp65; Slp-65
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
Polyclonal IgG
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Clone
Polyclonal antibody
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Host organism
Rabbit
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Species reactivity
Mouse
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Specificity and cross reactivity
BLNK This item recognises B-cell Linker Protein (BLNK), a cytosolic adaptor molecule, visualised as two phosphoproteins of 68 and 70kDa in SDS/PAGE. _x000D__x000D_BLNK plays a pivotal role in B cell activation through cross-linkage of the B-cell Receptor (BCR), leading to the activation of protein tyrosine kinases (PTKs) including syk. The resulting tyrosine phosphorylation of BLNK by syk, provides docking sites for the SH2-containing effector molecules such as Vav, PLC gamma and the adaptor proteins Crb2 and Nck, thereby acting as a central linker protein in many different B cell signalling pathways involved in proliferation, differentiation and apoptosis.
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Purification method
N/A
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Form Appearance
Purified (Purified IgG - liquid)
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Concentration
Ig concentration 1.0 mg/ml
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Storage and shipping
Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. productone should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.
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Tested for
Western Blot (WB)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
