TrkB Antibody

• Catalog number
  R32247
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TrkB
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml
• Notes
  Optimal dilution of the TrkB antibody should be determined by the researcher.
• Intented use
  This TrkB antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q16620
• Purity
  Antigen affinity
• Description
  TrkB is also known as NTRK2. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. Tropomyosin receptor kinase B is the high affinity catalytic receptor for several neurotrophins, which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival.
• Immunogen
  Amino acids 66-242 of human TrkB were used as the immunogen for the TrkB antibody.
• Storage
  After reconstitution, the TrkB antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TrkB  
• Gene symbol
  NTRK2
• Short name
  Anti-TrkB
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to TrkB
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8032
• Gene
  NTRK2
• Long gene name
  neurotrophic receptor tyrosine kinase 2
• Synonyms gene name
  • neurotrophic tyrosine kinase, receptor, type 2
• Synonyms
  • TRKB
• Synonyms name
  • BDNF/NT-3 growth factors receptor
• GenBank acession
  • AF410902
• Locus
  9q21.33
• Discovery year
  1991-07-18
• Entrez gene record
  4915
• Pubmed identfication
  • 7789988
• Classification
  • Receptor tyrosine kinases
  • I-set domain containing
• VEGA ID
  OTTHUMG00000020120

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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