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TGFBR2 Tyr259 Antibody , Cy5 Conjugated

  • Catalog number
    bs-18066R-Cy5
  • Product name
    TGFBR2 Tyr259 Antibody , Cy5 Conjugated
  • Size
    0.1ml
  • Price
    368EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
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  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
  • Modification site
    Tyr259
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    TGFBR2 Tyr259 Polyclonal Antibody , Cy5 Conjugated
  • Subcellular location
    Cytoplasm
  • Synonyms
    AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2
  • Gene ID number
    7048
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    Cy5
  • Modification
    Phosphorylation
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthesised phosphopeptide derived from human TGF beta Receptor II around the phosphorylation site of Tyr259
  • Swiss Prot
    P37173
  • Specificity
    This is a highly specific antibody against TGFBR2 Tyr259.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    TGFBR2 Tyr259
  • Immunogen_range
    250-270/567
  • Excitation Emission
    625,650nm/670nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
  • Additional conjugation
    Cy5.5
  • Gene target
  • Short name
    TGFBR2 Tyr259 Antibody Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    Cy5
  • Alternative name
    transforming growth factor, b receptor II (70/80kDa) Tyr259 (Antibody to) , cyanine 5 coupled
  • Alternative technique
    antibodies
  • Alternative to gene target
    transforming growth factor, beta receptor II (70/80kDa), AAT3 and FAA3 and LDS1B and LDS2 and LDS2B and MFS2 and RIIC and TAAD2 and TGFbeta-RII and TGFR-2, TGFBR2 and IDBG-23359 and ENSG00000163513 and 7048, this GO :0001568 and blood vessel development and biological process this GO :0001569 and patterning of blood vessels and biological process this GO :0001570 and vasculogenesis and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0002088 and lens development in camera-type eye and biological process this GO :0002651 and positive regulation of tolerance induction to self antigen and biological process this GO :0002663 and positive regulation of B cell tolerance induction and biological process this GO :0002666 and positive regulation of T cell tolerance induction and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005026 and transforming growth factor beta receptor activity, type II and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005539 and glycosaminoglycan binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007182 and common-partner SMAD protein phosphorylation and biological process this GO :0007224 and smoothened signaling pathway and biological process this GO :0007369 and gastrulation and biological process this GO :0007420 and brain development and biological process this GO :0007507 and heart development and biological process this GO :0007566 and embryo implantation and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0009749 and response to glucose and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010033 and response to organic substance and biological process this GO :0010634 and positive regulation of epithelial cell migration and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030324 and lung development and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0031100 and organ regeneration and biological process this GO :0031435 and mitogen-activated protein kinase kinase kinase binding and molecular function this GO :0032147 and activation of protein kinase activity and biological process this GO :0034713 and type I transforming growth factor beta receptor binding and molecular function this GO :0034714 and type III transforming growth factor beta receptor binding and molecular function this GO :0035162 and embryonic hemopoiesis and biological process this GO :0042060 and wound healing and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042493 and response to drug and biological process this GO :0043011 and myeloid dendritic cell differentiation and biological process this GO :0043235 and receptor complex and cellular component this GO :0043415 and positive regulation of skeletal muscle tissue regeneration and biological process this GO :0043627 and response to estrogen and biological process this GO :0045121 and membrane raft and cellular component this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0048545 and response to steroid hormone and biological process this GO :0048565 and digestive tract development and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0048701 and embryonic cranial skeleton morphogenesis and biological process this GO :0050431 and transforming growth factor beta binding and molecular function this GO :0051138 and positive regulation of NK T cell differentiation and biological process this GO :0051216 and cartilage development and biological process this GO :0060021 and palate development and biological process this GO :0060044 and negative regulation of cardiac muscle cell proliferation and biological process this GO :0060389 and pathway-restricted SMAD protein phosphorylation and biological process this GO :0060425 and lung morphogenesis and biological process this GO :0060433 and bronchus development and biological process this GO :0060434 and bronchus morphogenesis and biological process this GO :0060439 and trachea morphogenesis and biological process this GO :0060440 and trachea formation and biological process this GO :0060443 and mammary gland morphogenesis and biological process this GO :0060463 and lung lobe morphogenesis and biological process this GO :0070022 and transforming growth factor beta receptor homodimeric complex and cellular component this GO :0070723 and response to cholesterol and biological process this GO :1990086 and lens fiber cell apoptotic process and biological process this GO :2000379 and positive regulation of reactive oxygen species metabolic process and biological process, transforming growth factor beta receptor activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004675: transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702: receptor signaling protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004872: receptor activity and also this GO :0005024: transforming growth factor beta-activated receptor activity and also this GO :0005026: transforming growth factor beta receptor activity, type II and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0005539: glycosaminoglycan binding and also this GO :0016772: transferase activity, transferring phosphorus-containing groups and also this GO :0031435: mitogen-activated protein kinase kinase kinase binding and also this GO :0034713: type I transforming growth factor beta receptor binding and also this GO :0034714: type III transforming growth factor beta receptor binding and also this GO :0046332: SMAD binding and also this GO :0046872: metal ion binding and also this GO :0050431: transforming growth factor beta binding, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004675: transmembrane receptor protein serine/threonine kinase activity, this GO :0004702: receptor signaling protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004872: receptor activity, this GO :0005024: transforming growth factor beta-activated receptor activity, this GO :0005026: transforming growth factor beta receptor activity, type II, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0005539: glycosaminoglycan binding, this GO :0016772: transferase activity, transferring phosphorus-containing groups, this GO :0031435: mitogen-activated protein kinase kinase kinase binding, this GO :0034713: type I transforming growth factor beta receptor binding, this GO :0034714: type III transforming growth factor beta receptor binding, this GO :0046332: SMAD binding, this GO :0046872: metal ion binding, this GO :0050431: transforming growth factor beta binding, Cell surfaces, Tgfbr2 and IDBG-203902 and ENSMUSG00000032440 and 21813, BT.66001 and IDBG-644071 and ENSBTAG00000019832 and 535376
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1. Gene info
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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