Filters
US: (408) 780-0908 | EU: 0032 16 58 90 45 lieven@gentaur.com
Total records: 2669947. Total pages:Pages 53399 First Current page: 1 Last

TAK1(Thr187) Antibody, HRP Conjugated

  • Catalog number
    bs-3438R-HRP
  • Product name
    TAK1(Thr187) Antibody, HRP Conjugated
  • Size
    0.1ml
  • Price
    368EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.
  • Modification site
    Thr187
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    TAK1(Thr187) Polyclonal Antibody, HRP Conjugated
  • Subcellular location
    Cytoplasm
  • Synonyms
    TAK1; MEKK7; TGF1a; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; MAP3K7
  • Gene ID number
    6885
  • Recommended dilutions
    WB(1:100-1000), IHC-P(1:100-500)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    HRP
  • Modification
    Phosphorylation
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Thr187
  • Swiss Prot
    O43318
  • Specificity
    This is a highly specific antibody against TAK1 Thr187.
  • Tested applications
    WB, IHC-P
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    TAK1 Thr187
  • Immunogen_range
    180-190/606
  • Excitation Emission
    N/A
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
  • Additional conjugation
    HRP Conjugated
  • Gene target
  • Short name
    TAK1(Thr187) Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    HRP
  • Alternative name
    TAK1(Thr187) (Antibody to), horseradish peroxidase coupled
  • Alternative technique
    antibodies
  • Ask
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
Product images
Related products
Chat with gentaur.com employee