ROCK2 Antibody, HRP Conjugated

  • Catalog number
    bs-1205R-HRP
  • Price
    Please ask
  • Size
    0.1ml
  • Long name
    ROCK2 Polyclonal Antibody, HRP Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    HRP
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    ROCK2
  • Specificity
    This is a highly specific antibody against ROCK2.
  • Modification
    Unmodified
  • Modification site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Immunogen_range
    1035-1085/1388
  • Subcellular location
    Cytoplasm
  • Source
    KLH conjugated synthetic peptide derived from human ROCK2
  • Gene ID number
    9475
  • Swiss Prot
    O75116
  • Tested applications
    WB, IHC-P
  • Recommended dilutions
    WB(1:100-1000), IHC-P(1:100-500)
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP3, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p9RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    N/A
  • Synonyms
    ROCK-II; Rho-associated protein kinase 2; Rho kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; p164 ROCK-2; ROCK2; KIAA619
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
  • Additional conjugation
    HRP Conjugated
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    ROCK2
  • Short name
    Anti-ROCK2
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Isotype
    Immunoglobulin G (IgG)
  • Label
    HRP
  • Alternative name
    Anti-ROCK2 PAb HRP
  • Alternative technique
    antibodies
  • Alternative to gene target
    Rho-associated, coiled-coil containing protein kinase 2, ROCK-II, ROCK2 and IDBG-29657 and ENSG00000134318 and 9475, transferase activity, nuclei, Rock2 and IDBG-129486 and ENSMUSG00000020580 and 19878, ROCK2 and IDBG-638012 and ENSBTAG00000005847 and 282041
Gene info
  • Identity
  • Gene
  • Long gene name
    Rho associated coiled-coil containing protein kinase 2
  • GenBank acession
  • Locus
  • Discovery year
    1999-04-23
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Pleckstrin homology domain containing
    • AGC family kinases
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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