RICTOR Antibody

• Catalog number
  F53372-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  RICTOR
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:2000
• Notes
  Titration of the RICTOR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This RICTOR antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q6R327
• Purity
  Antigen affinity
• Description
  Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
• Immunogen
  This RICTOR antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1068-1102 amino acids from the Central region of human RICTOR.
• Storage
  Aliquot the RICTOR antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  RICTOR  
• Gene symbol
  RICTOR
• Short name
  Anti-RICTOR
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to RICTOR
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:28611
• Gene
  RICTOR
• Long gene name
  RPTOR independent companion of MTOR complex 2
• Synonyms gene name
  • RPTOR independent companion of MTOR, complex 2
• Synonyms
  • MGC39830
  • AVO3
  • PIA
  • KIAA1999
• Synonyms name
  • rapamycin-insensitive companion of mTOR
  • pianissimo
• Locus
  5p13.1
• Discovery year
  2009-05-29
• Entrez gene record
  253260
• Pubmed identfication
  • 15268862
• RefSeq identity
  • NM_152756
• Classification
  • MTOR complex 2
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000162037

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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