Rabbit anti TACE (CT) antibody ADAM 17 (CT) antibody (TNFa Converting Enz)

  • Catalog number
    X1123P
  • Price
    Please ask
  • Size
    100 μg
  • Category
    Primary Antibodies
  • Long description
    Tumor-necrosis factor- is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF- is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF- . TNF- converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately (1-3). TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGF , the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. (6)
  • Antibody come from
    Synthetic peptide corresponding to amino acids 807 to 823 of the human TACE protein. Immunogen sequence differs from the mouse and rat sequences by one amino acid.
  • Other description
    Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative. Antigen Immunoaffiinity Purification
  • Clone
    Polyclonal
  • Antigen antibody binding interaction
    Rabbit anti TACE (CT) antibody ADAM 17 (CT) antibody (TNFa Converting Enz) Antibody
  • Antibody is raised in
    Rabbit
  • Antibody s reacts with
    Human, Mouse, Rat
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Antibody s specificity
    No Data Available
  • Application
    Western Blot
  • Antibody s suited for
    Detects TACE by Western blot at 0.25 to 1 µg/ml. Detects an approximately 130 kDa band in HeLa and Jurkat whole cell lysate which may represent mature protein, precursor, and glycosylated TACE. Optimal concentration should be evaluated by serial dilutions.
  • Storage
    -20ºC
  • Relevant references
    1. Black, R.A., et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 1997, 385, 729-733_x000B__x000B_2. Moss, M.L., et al. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. Nature 1997, 385, 733-736_x000B__x000B_3. Mizui, Y., et al., cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter. Gene 1999, 233, 67-74 _x000B__x000B_4. Peschon, J.J., et al. An essential role for ectodomain shedding in mammalian development. Science 1998, 282, 1281-4_x000B__x000B_5. Buxbaum, J.D., et al. Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 1998, 273, 27765-27767 _x000B__x000B_6. Giegel, D.A. and Chaplin, D.D. Targets in cytokine activation. Agents Actions Suppl. 1998, 49, 1-3_x000B__x000B_7. Blaydon, D.C, et al. Imflammatory Skin and Bowel Disease Linked to ADAM17 Deletion N Engl J Med, 2011, 365, 1502-1508_x000B_
  • Protein number
    see ncbi
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by nordc they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • About
    Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
  • Latin name
    Oryctolagus cuniculus
  • French translation
    anticorps
  • Gene target
    TACE   ADAM   TNFa   Converting   Enz  
  • Gene symbol
    ADAMTS10, ADAMTS6, ADAMTS8, ADAM17, ADAMTS7, ADAMTS2
  • Short name
    Rabbit anti TACE (CT) antibody ADAM 17 (CT) antibody (TNFa Converting Enz)
  • Technique
    Antibody, Rabbit, anti, antibody to, antibodies against human proteins, antibodies for
  • Host
    Rabbit, Rabbits
  • Isotype
    not specified
  • Label
    unlabeled
  • Alternative name
    production species: rabbit antibody to TACE (CT) (antibody to-) ADAM 17 (CT) (antibody to-) (TNFa Converting Enz)
  • Alternative technique
    antibodies, rabbit-anti
Gene info
  • Identity
  • Gene
  • Long gene name
    ADAM metallopeptidase with thrombospondin type 1 motif 10
  • Synonyms gene name
    • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-04-05
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • ADAM metallopeptidases with thrombospondin type 1 motif
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    ADAM metallopeptidase with thrombospondin type 1 motif 8
  • Synonyms gene name
    • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1999-08-23
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • ADAM metallopeptidases with thrombospondin type 1 motif
  • VEGA ID
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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