presenilin 2/PS-2 Antibody, FITC Conjugated

• Catalog number
  bs-3815R-FITC
• Price
  Please ask
• Size
  0.1ml

• Long name
  presenilin 2/PS-2 Polyclonal Antibody, FITC Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  FITC
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  presenilin 2/PS-2
• Specificity
  This is a highly specific antibody against presenilin 2/PS-2.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic peptide derived from human presenilin 2/PS-2
• Gene ID number
  5664
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  494nm/518nm
• Synonyms
  AD 3L; AD 3LP; AD 4; AD 5; AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; Alzheimer disease familial type 4; E5 1; Presenilin2; Presenilin 2; Presenilin 2; PS 2; PS2; PSEN 2; PSNL 2; PSNL2; STM 2; STM2.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
• Additional conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  presenilin   2/PS-2   Conjugated  
• Gene symbol
  CAVIN2, PLA1A, TFF1, FABP3P2, PRB2, ARMCX7P, PSEN2, MIR7-2, MIR329-2, MIR512-2
• Short name
  Anti-presenilin 2/PS-2
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
• Isotype
  Immunoglobulin G (IgG)
• Label
  FITC
• Alternative name
  Anti-presenilin 2/PS-2 PAb FITC
• Alternative technique
  antibodies, fluorescine

Gene info

• Identity
  HGNC:10690
• Gene
  CAVIN2
• Long gene name
  caveolae associated protein 2
• Synonyms gene
  • SDPR
• Synonyms gene name
  • serum deprivation response (phosphatidylserine-binding protein)
  • serum deprivation response (phosphatidylserine binding protein)
  • serum deprivation response
• Synonyms
  • SDR
  • PS-p68
  • cavin-2
• Synonyms name
  • phosphatidylserine binding protein
• GenBank acession
  • AF085481
• Locus
  2q32.3
• Discovery year
  1998-10-30
• Entrez gene record
  8436
• Pubmed identfication
  • 10191091
  • 8241023
• RefSeq identity
  • NM_004657
• Classification
  • Cavins
• VEGA ID
  OTTHUMG00000154309

Gene info

• Identity
  HGNC:17661
• Gene
  PLA1A
• Long gene name
  phospholipase A1 member A
• Synonyms
  • ps-PLA1
• GenBank acession
  • AF035268
• Locus
  3q13.33
• Discovery year
  2002-11-28
• Entrez gene record
  51365
• Pubmed identfication
  • 10196188
• Classification
  • Phospholipases
• VEGA ID
  OTTHUMG00000159425

Gene info

• Identity
  HGNC:11755
• Gene
  TFF1
• Long gene name
  trefoil factor 1
• Synonyms gene
  • BCEI
• Synonyms gene name
  • breast cancer, estrogen-inducible sequence expressed in
• Synonyms
  • D21S21
  • HPS2
  • pS2
  • pNR-2
  • HP1.A
• GenBank acession
  • BC032811
• Locus
  21q22.3
• Discovery year
  2001-06-22
• Entrez gene record
  7031
• Pubmed identfication
  • 9043862
• RefSeq identity
  • NM_003225
• VEGA ID
  OTTHUMG00000086799

Gene info

• Identity
  HGNC:3558
• Gene
  FABP3P2
• Long gene name
  fatty acid binding protein 3 pseudogene 2
• Synonyms
  • FABP3-ps
  • FABP3P
• GenBank acession
  • U72237
• Locus
  13q14.11
• Discovery year
  2000-07-31
• Entrez gene record
  56677
• Pubmed identfication
  • 9256083
• VEGA ID
  OTTHUMG00000016806

Gene info

• Identity
  HGNC:9338
• Gene
  PRB2
• Long gene name
  proline rich protein BstNI subfamily 2
• Synonyms
  • PRPPRB1
  • Ps
  • cP7
• GenBank acession
  • K03208
• Locus
  12p13.2
• Discovery year
  2001-06-22
• Entrez gene record
  653247
• Pubmed identfication
  • 8554050
• RefSeq identity
  • NM_006248
• Classification
  • Proline rich proteins
• VEGA ID
  OTTHUMG00000156975

Gene info

• Identity
  HGNC:49917
• Gene
  ARMCX7P
• Long gene name
  armadillo repeat containing X-linked 7, pseudogene
• Synonyms
  • ARMCX6-ps
  • GASP10ps
• Locus
  Xq22.1
• Discovery year
  2014-03-21
• Entrez gene record
  653354
• Pubmed identfication
  • 16221301
  • 22569362
• VEGA ID
  OTTHUMG00000022036

Gene info

• Identity
  HGNC:9509
• Gene
  PSEN2
• Long gene name
  presenilin 2
• Synonyms gene
  • AD4
• Synonyms gene name
  • Alzheimer disease 4
• Synonyms
  • AD3L
  • STM2
  • PS2
• GenBank acession
  • BC006365
• Locus
  1q42.13
• Discovery year
  1995-08-30
• Entrez gene record
  5664
• Pubmed identfication
  • 7638621
• RefSeq identity
  • NM_000447
• Classification
  • Peptidase family A22
• VEGA ID
  OTTHUMG00000037563
• Locus Specific Databases
  • Alzheimer Disease & Frontotemporal Dementia Mutation Database
  • LRG_225

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

MeSH Data

• Name
  Fluorescent Antibody Technique
• Concept
  Scope note: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
• Tree numbers
  • E01.370.225.500.607.512.240
  • E01.370.225.750.551.512.240
  • E05.200.500.607.512.240
  • E05.200.750.551.512.240
  • E05.478.583.375
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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