presenilin 2/PS-2 Antibody, Cy5.5 Conjugated
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Catalog numberbs-3815R-Cy5.5
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PricePlease ask
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Size0.1ml
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Long namepresenilin 2/PS-2 Polyclonal Antibody, Cy5.5 Conjugated
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CategoryConjugated Primary Antibodies
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ConjugationCy5.5
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target Antigenpresenilin 2/PS-2
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SpecificityThis is a highly specific antibody against presenilin 2/PS-2.
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ModificationUnmodified
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Modification siteNone
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic peptide derived from human presenilin 2/PS-2
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Gene ID number5664
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman, Mouse, Rat
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Crossreactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Antigen backgroundAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
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Excitation Emission675nm/694nm
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SynonymsAD 3L; AD 3LP; AD 4; AD 5; AD3L; AD3LP; AD4; AD5; Alzheimer disease 4; Alzheimer disease familial type 4; E5 1; Presenilin2; Presenilin 2; Presenilin 2; PS 2; PS2; PSEN 2; PSNL 2; PSNL2; STM 2; STM2.
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PropertiesIf you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
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Additional conjugationCy5.5, Cy5.5
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ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694Â nm wavelengths.
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French translationanticorps
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Gene target
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Gene symbolCAVIN2, PLA1A, TFF1, FABP3P2, PRB2, ARMCX7P, PSEN2, MIR1289-2, MIR521-2, MIR509-2
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Short nameAnti-presenilin 2/PS-2
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TechniqueAntibody, antibodies against human proteins, antibodies for, antibody Conjugates
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IsotypeImmunoglobulin G (IgG)
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LabelCy5.5
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Alternative nameAnti-presenilin 2/PS-2 PAb Cy5.5
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namecaveolae associated protein 2
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Synonyms gene
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Synonyms gene name
- serum deprivation response (phosphatidylserine-binding protein)
- serum deprivation response (phosphatidylserine binding protein)
- serum deprivation response
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-10-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Cavins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namephospholipase A1 member A
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-11-28
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Entrez gene record
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Pubmed identfication
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Classification
- Phospholipases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametrefoil factor 1
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Synonyms gene
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Synonyms gene name
- breast cancer, estrogen-inducible sequence expressed in
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namefatty acid binding protein 3 pseudogene 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-07-31
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameproline rich protein BstNI subfamily 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Proline rich proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namearmadillo repeat containing X-linked 7, pseudogene
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Synonyms
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Locus
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Discovery year2014-03-21
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namepresenilin 2
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Synonyms gene
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Synonyms gene name
- Alzheimer disease 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-08-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Peptidase family A22
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemicroRNA 1289-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2008-11-03
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR1289 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 521-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2005-07-15
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR515 family
Gene info
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Identity
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Gene
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Long gene namemicroRNA 509-2
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Synonyms gene
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Synonyms
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Locus
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Discovery year2007-10-24
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNA MIR506 family
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data