P105 RB Antibody, Cy7 Conjugated

• Catalog number
  bs-2777R-Cy7
• Price
  Please ask
• Size
  0.1ml

• Long name
  P105 RB Polyclonal Antibody, Cy7 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy7
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  P105 RB
• Specificity
  This is a highly specific antibody against P105 RB.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  68-116/928
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic peptide derived from human Rb/P105 RB
• Gene ID number
  5925
• Swiss Prot
  P06400
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV42H1 and SUV42H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-2' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV4 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  743nm/767nm
• Synonyms
  RB; pRb; OSRC; pp11; p15-Rb; PPP1R13; Retinoblastoma-associated protein; RB1
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugated
  These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
• Additional conjugation
  Cy7
• French translation
  anticorps

• Gene target
  P105   Conjugated  
• Gene symbol
  NFKB2, SCYL1, NFKB1
• Short name
  Anti-P105 RB
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy7
• Alternative name
  Anti-P105 RB PAb Cy7
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7795
• Gene
  NFKB2
• Long gene name
  nuclear factor kappa B subunit 2
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
• Synonyms
  • LYT-10
  • p52
  • p105
  • NF-kB2
  • p49/p100
• GenBank acession
  • X61498
• Locus
  10q24.32
• Discovery year
  1991-11-14
• Entrez gene record
  4791
• Pubmed identfication
  • 1876189
• Classification
  • IPT domain containing
  • NF-kappa B complex subunits
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000018962
• Locus Specific Databases
  • LRG_1347

Gene info

• Identity
  HGNC:14372
• Gene
  SCYL1
• Long gene name
  SCY1 like pseudokinase 1
• Synonyms gene
  • NTKL
• Synonyms gene name
  • N-terminal kinase-like
  • SCY1-like 1 (S. cerevisiae)
  • SCY1-like, kinase-like 1
• Synonyms
  • HT019
  • P105
  • GKLP
  • NKTL
  • TAPK
  • TRAP
  • TEIF
  • MGC78454
• Synonyms name
  • teratoma-associated tyrosine kinase
  • telomerase transcriptional elements-interacting factor
  • telomerase regulation-associated protein
• GenBank acession
  • AF225424
• Locus
  11q13.1
• Discovery year
  2001-01-16
• Entrez gene record
  57410
• Pubmed identfication
  • 11118629
• RefSeq identity
  • NM_020680
• Classification
  • Armadillo like helical domain containing
  • SCY1 like pseudokinases
• VEGA ID
  OTTHUMG00000166325

Gene info

• Identity
  HGNC:7794
• Gene
  NFKB1
• Long gene name
  nuclear factor kappa B subunit 1
• Synonyms gene name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
• Synonyms
  • KBF1
  • p105
  • NFKB-p50
  • p50
  • NF-kappaB
  • NFkappaB
  • NF-kB1
• Synonyms name
  • Nuclear factor NF-kappa-B p105 subunit
• GenBank acession
  • M58603
• Locus
  4q24
• Discovery year
  1991-11-14
• Entrez gene record
  4790
• Pubmed identfication
  • 1992489
• RefSeq identity
  • NM_003998
• Classification
  • NF-kappa B complex subunits
  • Ankyrin repeat domain containing
  • IPT domain containing
• VEGA ID
  OTTHUMG00000161080
• Locus Specific Databases
  • LRG_1316

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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