Oncostatin M Antibody

• Catalog number
  PB9732
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Oncostatin M
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB,IHC-P,ELISA
• Immunogen
  E. coli-derived human Oncostatin M recombinant protein (Position: A26-R220). Human Oncostatin M shares 47.1% and 47.6% amino acid (aa) sequence identity with mouse and rat Oncostatin M, respectively.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Oncostatin M Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Oncostatin M Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.
• Related articles
  1. Miles, S. A., Martinez-Maza, O., Rezai, A., Magpantay, L., Kishimoto, T., Nakamura, S., Radka, S. F., Linsley, P. S. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255: 1432-1434, 1992. 2. Modur, V., Feldhaus, M. J., Weyrich, A. S., Jicha, D. L., Prescott, S. M., Zimmerman, G. A., McIntyre, T. M. Oncostatin M is a proinflammatory mediator: in vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. J. Clin. Invest. 100: 158-168, 1997. 3. Rose, T. M., Bruce, A. G. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Nat. Acad. Sci. 88: 8641-8645, 1991.
• Gene Name
  OSM
• Protein Name
  Oncostatin-M
• Gene Full Name
  oncostatin M
• Synonyms
  MGC20461 antibody|ONCM_HUMAN antibody|Oncostatin M antibody|Oncostatin M precursor antibody|Oncostatin-M antibody|OSM antibody
• Uniprot ID
  P13725
• Entrez GeneID
  5008
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Oncostatin  
• Gene symbol
  OSMR, OSM, IL6STP1
• Short name
  Oncostatin M Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Oncostatin M (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8507
• Gene
  OSMR
• Long gene name
  oncostatin M receptor
• Synonyms
  • OSMRB
  • OSMRbeta
• Synonyms name
  • Oncostatin-M-specific receptor subunit beta
• GenBank acession
  • U60805
• Locus
  5p13.1
• Discovery year
  1999-02-17
• Entrez gene record
  9180
• Pubmed identfication
  • 8999038
• RefSeq identity
  • NM_003999
• Classification
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000090811

Gene info

• Identity
  HGNC:8506
• Gene
  OSM
• Long gene name
  oncostatin M
• Synonyms
  • MGC20461
• GenBank acession
  • AF129855
• Locus
  22q12.2
• Discovery year
  1992-07-09
• Entrez gene record
  5008
• Pubmed identfication
  • 1717982
• RefSeq identity
  • NM_020530
• Classification
  • Interleukin 6 type cytokine family
• VEGA ID
  OTTHUMG00000150913

Gene info

• Identity
  HGNC:6022
• Gene
  IL6STP1
• Long gene name
  interleukin 6 signal transducer pseudogene 1
• Synonyms gene
  • IL6STP
• Synonyms gene name
  • interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene
  • interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene 1
• Locus
  17p12
• Discovery year
  1995-05-16
• Entrez gene record
  3573
• Pubmed identfication
  • 7736792
• RefSeq identity
  • NG_002748
• VEGA ID
  OTTHUMG00000059144

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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