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Target antigen
NMDAR2A
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB
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Immunogen
E.coli-derived human NMDAR2A recombinant protein (Position: D958-R1300). Human NMDAR2A shares 89% and 90% amino acid (aa) sequence identity with mouse and rat NMDAR2A, respectively.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the NMDAR2A Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The NMDAR2A Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
GRIN2A is also known as N-methyl-D-aspartate receptor channel, subunit epsilon-1(NMDAR2A). This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.
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Related articles
1. Kalsi, G.; Whiting, P.; Le Bourdelles, B.; Callen, D.; Barnard, E. A.; Gurling, H. : Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels. Genomics 47: 423-425, 1998. 2. Micu, I.; Jiang, Q.; Coderre, E.; Ridsdale, A.; Zhang, L.; Woulfe, J.; Yin, X.; Trapp, B. D.; McRory, J. E.; Rehak, R.; Zamponi, G. W.; Wang, W.; Stys, P. K. : NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 439: 988-992, 2006.
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Gene Name
GRIN2A
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Protein Name
Glutamate receptor ionotropic, NMDA 2A
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Gene Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
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Synonyms
Glutamate [NMDA] receptor subunit epsilon 1 antibody|Glutamate [NMDA] receptor subunit epsilon-1 antibody|Glutamate receptor antibody|Glutamate receptor ionotropic N methyl D aspartate 2A antibody|GRIN 2A antibody|GRIN2A antibody|HNR2A antibody|N methyl D aspartate receptor channel, subunit epsilon 1 antibody|N Methyl D Aspartate Receptor Subtype 2A antibody|N methyl D aspartate receptor subunit 2A antibody|N-methyl D-aspartate receptor subtype 2A antibody|NMDA receptor subtype 2A antibody|NMDA Receptor Type 2A antibody|NMDAR 2A antibody|NMDAR2A antibody|NMDE1_HUMAN antibody|NR 2A antibody|NR2A antibody|OTTHUMP00000160135 antibody|OTTHUMP00000174531 antibody
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Uniprot ID
Q12879
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Entrez GeneID
2903
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
